This core will provide essential administrative services and support for the UTSW Kidney Cancer SPORE. The PI, Dr. Brugarolas, is well-suited to provide overall direction, facilitate interactions, provide scientific leadership, and oversee the fiscal management of this complex grant. His scientific background, history of participation in many aspects of translational science, and current administrative roles at UTSW (including Leader of the Kidney Cancer Program (KCP) and member of the scientific leadership of the NCI-designated, now comprehensive, Simmons Cancer Center) make him well-qualified to serve as overall PI and Core Director. He is aided by Core A Co-Directors, Dr. Sagalowsky (Professor of Urology and Surgery, and a KCP Urology co-Leader), and Dr. McKay (KCP Director of Research Administration), and a first-rate administrative team. An Executive Committee (Project Leaders and Core Directors) provides advice for the planning of SPORE strategic directions, interactions with departments and administration, faculty recruitment, and resource allocation. The KCP and SPORE are well-integrated within the Cancer Center and benefit from many shared resources. Institutional commitment is illustrated by (i) participation in the IAB of outstanding investigators and institutional leaders, and (ii) a significant financial commitment, including $1,100,000 in annual direct support for salaries, benefits and operating costs of key investigators and their laboratories, and recurring annual funds of: $150,000 (to match CEP and DRP), $150,000 (to support the Data Analytics Core), and $50,000 (discretionary funds). In addition, $1,100,000 in recruitment funds will be made available. The SPORE includes a dynamic patient advocacy team of engaged individuals who have participated extensively in the KCP, including fundraising, raising awareness, and social events. Our outstanding EAB includes leaders in their fields with complementary expertise in clinical/translational research (Arteaga, George, Michaelson, Nelson, Oh, Ratain, and Shyr), epidemiological research (Heng and Shyr), and basic research (Simon). The Core A aims are straightforward and should fulfill the objective of organizing a complex network of interactions involving numerous investigators, staff, cores, and advocates: (1) Oversee and direct all scientific and administrative aspects of the SPORE including research/data management, fiscal oversight and adherence, and communication aspects: (a) Oversee and maintain scientific quality and rigor of the SPORE; (b) Record, monitor, and oversee all budgetary items; (c) Monitor and ensure all aspects of SPORE compliance following NCI regulations and requirements, and communicate with NCI Program Officer (and other staff) to ensure compliance with reporting; (d) Schedule and organize all meetings, including meetings with the Advisory Boards, and Patient Advocates. (2) Oversee and coordinate with the Developmental Research Program and the Career Enhancement Program to provide fiscal, organizational, and outreach support. (3) Coordinate and oversee Patient Advocate Program activities. (4) Oversee and facilitate resolution of scientific disputes.

Public Health Relevance

The Administrative Core (Core A) of the UTSW Kidney Cancer SPORE is the organizing ?hub? of the SPORE, and provides both administrative and scientific oversight for all of the SPORE Projects and Cores, the Patient Advocate Program, and the Developmental Research and Career Enhancement Programs. This oversight includes compliance, reporting, and budgetary issues, coordinating all SPORE meetings, and interfacing with the SPORE IAB, EAB, Patient Advocates, and external collaborators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA196516-05
Application #
9990721
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2016-08-01
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Puertollano, Rosa; Ferguson, Shawn M; Brugarolas, James et al. (2018) The complex relationship between TFEB transcription factor phosphorylation and subcellular localization. EMBO J 37:
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O'Kelly, Devin; Zhou, Heling; Mason, Ralph P (2018) Tomographic breathing detection: a method to noninvasively assess in situ respiratory dynamics. J Biomed Opt 23:1-6
Wang, Xinzeng; Pirasteh, Ali; Brugarolas, James et al. (2018) Whole-body MRI for metastatic cancer detection using T2 -weighted imaging with fat and fluid suppression. Magn Reson Med 80:1402-1415
Courtney, Kevin D; Infante, Jeffrey R; Lam, Elaine T et al. (2018) Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2? Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma. J Clin Oncol 36:867-874
Krajewski, Katherine M; Pedrosa, Ivan (2018) Imaging Advances in the Management of Kidney Cancer. J Clin Oncol :JCO2018791236
Carbone, Michele; Amelio, Ivano; Affar, El Bachir et al. (2018) Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death Differ 25:1885-1904
Kay, Fernando U; Pedrosa, Ivan (2018) Imaging of Solid Renal Masses. Urol Clin North Am 45:311-330
Courtney, Kevin D; Bezwada, Divya; Mashimo, Tomoyuki et al. (2018) Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. Cell Metab 28:793-800.e2
Dwivedi, Durgesh Kumar; Chatzinoff, Yonatan; Zhang, Yue et al. (2018) Development of a Patient-specific Tumor Mold Using Magnetic Resonance Imaging and 3-Dimensional Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses. Urology 112:209-214

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