This project will undertake the radiochemical syntheses and in vivo evaluation in animals of new ligands for the mu, kappa and delta subtypes of the opiate receptor. Targets for synthesis include both agonists and antagonist ligands for these high affinity binding sites of the mammalian brain. Ligands were chosen for radiolabeling with carbon-11 or fluorine-18 on the basis of affinity, lipophilicity, potential routes of metabolism, and selectivity or specificity for opiate receptor subtypes. New radiolabeled compounds will be evaluated in mice, rats and primates for regional specificity of binding, pharmacokinetics, and metabolism. The goal of this Project is to identify suitable radioligands for quantification of opiate receptor subtypes in the living human brain using Positron Emission Tomography (PET), allowing studies of the role of these receptors in drug abuse and dependence, perception and regulation of pain, and psychiatric diseases.
| Moses, Tabitha E H; Lundahl, Leslie H; Greenwald, Mark K (2018) Factors associated with sedative use and misuse among heroin users. Drug Alcohol Depend 185:10-16 |
| Reilly, Mark P; Berndt, Sonja I; Woods, James H (2016) On the nature of directed behavior to drug-associated light cues in rhesus monkeys (Macaca mulatta). Behav Anal (Wash D C) 16:200-209 |
| Woodcock, Eric A; Lundahl, Leslie H; Stoltman, Jonathan J K et al. (2015) Progression to regular heroin use: examination of patterns, predictors, and consequences. Addict Behav 45:287-93 |
| Stoltman, Jonathan J K; Woodcock, Eric A; Lister, Jamey J et al. (2015) Heroin delay discounting: Modulation by pharmacological state, drug-use impulsivity, and intelligence. Exp Clin Psychopharmacol 23:455-63 |
| Stoltman, Jonathan J K; Woodcock, Eric A; Lister, Jamey J et al. (2015) Exploration of the telescoping effect among not-in-treatment, intensive heroin-using research volunteers. Drug Alcohol Depend 148:217-20 |
| Mancha, Brent Edward; Hulbert, Alicia; Latimer, William W (2012) A latent class analysis of alcohol abuse and dependence symptoms among Puerto Rican youth. Subst Use Misuse 47:429-41 |
| Moynihan, Humphrey A; Derrick, Ian; Broadbear, Jillian H et al. (2012) Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible ? opioid receptor antagonist effects. J Med Chem 55:9868-74 |
| Mancha, Brent E; Rojas, Vanessa C; Latimer, William W (2012) Alcohol use, alcohol problems, and problem behavior engagement among students at two schools in northern Mexico. Alcohol 46:695-701 |
| Pichika, Rama; Jewett, Douglas M; Sherman, Philip S et al. (2010) Synthesis and in vivo brain distribution of carbon-11-labeled ?-opioid receptor agonists. Nucl Med Biol 37:989-96 |
| Cooper, Ziva D; Shi, Yong-Gong; Woods, James H (2010) Reinforcer-dependent enhancement of operant responding in opioid-withdrawn rats. Psychopharmacology (Berl) 212:369-78 |
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