Drug abuse and drug dependence is the second most common mental health disorder among young women in American today. Recent survey data also indicate that abuse of marihuana, cocaine, tobacco and alcohol by women is increasing. Yet the PHS Task Force on Women's Health Issues (1985) noted that there has been relatively little research on the health consequences of substance use and recommended """"""""studies of the significant factors related to the onset, continuation and cessation of smoking, drinking and drug taking by women"""""""". The proposed clinical research center program focuses on the biological and behavioral antecedents, correlates and consequences of substance abuse by women. The safety and efficacy of new pharmacological treatments for cocaine, opiate and polydrug abuse will be evaluated in controlled inpatient and outpatient drug treatment programs. Parallel studies to determine if new pharmacotherapies effectively suppress cocaine self- administration in a female monkey drug self-administration model are proposed. Established operant behavioral procedures will be used to evaluate the dose range of pharmacotherapeutic efficacy and safety. Controlled clinical research ward studies are proposed to examine polydrug use patterns involving marihuana, alcohol and tobacco. Covariance between premenstrual dysphoria and drug use patterns will be examined. Neurobehavioral correlates of the development of tolerance to marihuana during chronic marihuana smoking will also be studied. Neurophysiologic and behavioral correlates of interactions between cocaine, marihuana and alcohol will be examined. Family history of substance abuse has been shown to be a significant factor in risk for polydrug abuse problems. The possible contribution of this antecedent risk factor to marihuana abuse will be evaluated by comparing sensitivity to the physiologic and behavioral effects of marihuana in women with and without a positive family history of alcohol abuse. Implementation of more effective drug abuse treatment programs and improved strategies for drug abuse prevention requires intensive analysis of biologic, behavioral and social concomitants of gender-related and gender specific factors in substance abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA004059-04
Application #
3105353
Study Section
(SRCD)
Project Start
1986-08-01
Project End
1991-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
Halpern, John H; Sholar, Michelle B; Glowacki, Julie et al. (2003) Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration. J Clin Endocrinol Metab 88:1188-93
Bowen, Carrie A; Negus, S Stevens; Kelly, Maureen et al. (2002) The effects of heroin on prolactin levels in male rhesus monkeys: use of cumulative-dosing procedures. Psychoneuroendocrinology 27:319-36
Caine, S Barak; Negus, S Stevens; Mello, Nancy K et al. (2002) Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J Neurosci 22:2977-88
Negus, Stevens S; Mello, Nancy K (2002) Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys. Psychopharmacology (Berl) 159:275-83
Mutschler, Nicole H; Stephen, Bruce J; Teoh, Siew Koon et al. (2002) An inpatient study of the effects of buprenorphine on cigarette smoking in men concurrently dependent on cocaine and opioids. Nicotine Tob Res 4:223-8
Negus, S Stevens; Mello, Nancy K (2002) Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy. J Pharmacol Exp Ther 300:1111-21
Mendelson, Jack H; Mello, Nancy K; Sholar, Michelle B et al. (2002) Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. Psychoneuroendocrinology 27:71-82
Kaufman, M J; Levin, J M; Maas, L C et al. (2001) Cocaine-induced cerebral vasoconstriction differs as a function of sex and menstrual cycle phase. Biol Psychiatry 49:774-81
Brandt, M R; Furness, M S; Mello, N K et al. (2001) Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther 296:939-46
Mello, N K; Negus, S S (2001) Effects of indatraline and buprenorphine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys. Neuropsychopharmacology 25:104-17

Showing the most recent 10 out of 100 publications