The Center for the Neurobiological Investigations of Drug Abuse (CNIDA) was established in 1991 by a grant from NIDA to support an integrated research program in the neuroscience of drug abuse at Bowman Gray School of Medicine at Wake Forest University.
The Specific Aims of the Center are: to provide an environment to promote collaborative and multi- disciplinary research into the neurobiological mechanisms of drug abuse among scientists at Bowman Gray School of Medicine; to provide a focus for the training of students and post-doctoral fellows in contemporary methods for investigation of the neurobiological basis of drug abuse; and to serve as an information source to both the lay and scientific community on issues related to the neurobiological aspects of drug abuse and to serve as the scientific reference for treatment and prevention programs in the community. The Center will accomplish these goals though the activities of three cores and eight projects over this next funding period. The cores Administration, Animal and Chemistry will provide services to the project that include an interdisciplinary research approach that spans from the molecular biology to non-human primate self-administration. Seventeen faculty will directly participate in Center research that includes individuals from the Departments of Physiology-Pharmacology and Radiology at Bowman Gray School of Medicine, and the Department of Chemistry at SUNY-Buffalo with expertise in receptor mechanisms, synthetic organic chemistry, medicinal chemistry, radiochemistry, neuroanatomy, positron emission tomography, neurochemistry, neuropharmacology, molecular biology, neurophysiology and rodent and primate behavioral pharmacology. These individuals will work together on CNIDA research projects directed toward a further understanding of the neuroscience of drug abuse. The Center will continue to provide research training for undergraduates, graduate students and postdoctoral fellow and serve as a resource on the physiology and neurobiology of drug abuse in scientific and lay communities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA006634-10
Application #
6329132
Study Section
Special Emphasis Panel (ZDA1-RXL-E (02))
Program Officer
Volman, Susan
Project Start
1991-09-30
Project End
2003-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
10
Fiscal Year
2001
Total Cost
$1,486,483
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Siciliano, Cody A; Saha, Kaustuv; Calipari, Erin S et al. (2018) Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci 38:484-497
Ilyasov, Alexander A; Milligan, Carolanne E; Pharr, Emily P et al. (2018) The Endocannabinoid System and Oligodendrocytes in Health and Disease. Front Neurosci 12:733
Ding, Huiping; Kiguchi, Norikazu; Yasuda, Dennis et al. (2018) A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med 10:
Chen, R; McIntosh, S; Hemby, S E et al. (2018) High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett 671:133-139
John, William S; Martin, Thomas J; Solingapuram Sai, Kiran Kumar et al. (2018) Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther 364:300-310
Siciliano, Cody A; McIntosh, J Michael; Jones, Sara R et al. (2017) ?6?2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology 126:281-291
Shaw, Jessica K; Ferris, Mark J; Locke, Jason L et al. (2017) Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol 22:1695-1705
Siciliano, Cody A; Jones, Sara R (2017) Cocaine Potency at the Dopamine Transporter Tracks Discrete Motivational States During Cocaine Self-Administration. Neuropsychopharmacology 42:1893-1904
Brodnik, Zachary D; Ferris, Mark J; Jones, Sara R et al. (2017) Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS Chem Neurosci 8:281-289
Fordahl, Steve C; Jones, Sara R (2017) High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling. ACS Chem Neurosci 8:290-299

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