Center for the Neurobiology of Addiction Treatment Pilot Studies Core Summary Dr. Sara Jones, Core Director The Center for the Neurobiology of Addiction Treatment (CNAT) Pilot Studies Program has proven to be an important mechanism for evolution of the Center by incorporating new and innovative project areas and technical expertise, and providing seed funding to junior investigators to help them obtain independent funding on their own. We are proposing a program with $30,000 available each year to fund one or two Pilot Projects. The selection process involves 1) a call for proposals and 2) analysis of the proposals by two non-Center reviewers, either from the External Advisory Board or ad-hoc scientists with particular technical or topical expertise relevant to the project. 3) The reviewers assign priority scores to the projects, and the highest scoring projects, usually 3-4, are 4) distributed to all Center investigators for evaluation, are discussed and rank- ordered by voting at one of the monthly Center meetings. This process provides the opportunity for open critique of Pilot Studies by all members of the Center, and often develops productive collaborative projects between CNAT and Pilot Study PI's. 5) Based on the rankings, final decisions for funding are made by the Pilot Studies Program Director. Rankings of pilot applications will be made according to the innovation and excellence of the research proposed, as well as its likely impact in the area of substance abuse research. Priority will be given to Studies that could have high impact, those most closely related to the theme of the Center, and those that may offer new technologies and research for future incorporation into CNAT.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA006634-26
Application #
9437780
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
26
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Siciliano, Cody A; Saha, Kaustuv; Calipari, Erin S et al. (2018) Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci 38:484-497
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Ding, Huiping; Kiguchi, Norikazu; Yasuda, Dennis et al. (2018) A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med 10:
Chen, R; McIntosh, S; Hemby, S E et al. (2018) High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett 671:133-139
John, William S; Martin, Thomas J; Solingapuram Sai, Kiran Kumar et al. (2018) Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther 364:300-310
Karkhanis, Anushree; Holleran, Katherine M; Jones, Sara R (2017) Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. Int Rev Neurobiol 136:53-88
Luessen, D J; Sun, H; McGinnis, M M et al. (2017) Chronic intermittent ethanol exposure selectively alters the expression of G? subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res 1672:106-112
Siciliano, Cody A; McIntosh, J Michael; Jones, Sara R et al. (2017) ?6?2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology 126:281-291
Shaw, Jessica K; Ferris, Mark J; Locke, Jason L et al. (2017) Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol 22:1695-1705
Siciliano, Cody A; Jones, Sara R (2017) Cocaine Potency at the Dopamine Transporter Tracks Discrete Motivational States During Cocaine Self-Administration. Neuropsychopharmacology 42:1893-1904

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