This Medications Development Research Center builds on the strengths and achievements of our existing Center, while developing innovative advances in medications development for opioids, cocaine, marijuana, and one of the (re)emerging drugs of concern, methamphetamine. We have created laboratory models for the initial evaluation of medications and developed procedures for the translation of our laboratory findings to the clinic. The major themes of the Center are: 1) model development, 2) targeted pharmacotherapy, 3) predictors of response, and 4) evaluating medications for emerging problems. The Center consists of 2 Cores and 5 Projects, among which there is considerable synergy and interdependency. Unifying all of the Projects are the Central Administrative Core (Core I) and the Biostatistics, Training and Education Core (Core II). Core I provides administrative and research support including research and nursing staff, clinical services, research facilities, laboratory resources, a centralized and standardized recruitment and screening program, and funding for pilot studies. The Biostatistics component of Core II provides the necessary statistical support for the Center and the Training and Education component of Core II is dedicated to education, training, mentoring in, as evidenced by our successful Substance Abuse Fellowship and extensive education (with our Fellowship program) to medical students, residents, and fellows. Project 1 will evaluate the ability of two glial inhibitors, ibudilast and minocycline, to alter prescription opioid self administration and relapse in humans. Project 2 will assess microglial inhibition for methamphetamine dependence using neuroimaging techniques in non-human primates and humans. Project 3 will employ the brain imaging techniques previously developed in Project 2 to the clinic by combining neuroimaging of dopamine transmission with a randomized clinical trial in cocaine-dependent individuals to evaluate the efficacy of medications that increase synaptic dopamine levels. Similarly, Project 4 will build on previous findings from Project 5 by conducting a randomized clinical trial comparing dronabinol + lofexidine to placebo for the treatment of cannabis dependence. Project 5 will now assess other potential triggers (proximal cues and priming) for marijuana relapse in the laboratory and test medications for each of these triggers. The thematic coherence between the Cores and the Projects is what allows our Center to foster original and creative contributions to the scientific understanding of medications development for drug abuse that is far greater than what could be achieved independently.

Public Health Relevance

This Medications Development Research Center is an integrative endeavor to develop innovative advances in medications development for a range of abused drugs. Our focus is to develop laboratory models to test potential medications and then translate these findings to the clinic. In addition, our Center is dedicated to training and mentoring young researchers and disseminating our research findings to other researchers and the community.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1-EXL-T (11))
Program Officer
Biswas, Jamie
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New York State Psychiatric Institute
New York
United States
Zip Code
Brezing, Christina A; Choi, C Jean; Pavlicova, Martina et al. (2018) Abstinence and reduced frequency of use are associated with improvements in quality of life among treatment-seekers with cannabis use disorder. Am J Addict 27:101-107
Cooper, Ziva D; Bedi, Gillinder; Ramesh, Divya et al. (2018) Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability. Neuropsychopharmacology 43:2046-2055
Chao, Thomas; Radoncic, Vanya; Hien, Denise et al. (2018) Stress responding in cannabis smokers as a function of trauma exposure, sex, and relapse in the human laboratory. Drug Alcohol Depend 185:23-32
Metz, Verena E; Sullivan, Maria A; Jones, Jermaine D et al. (2017) Racial Differences in HIV and HCV Risk Behaviors, Transmission, and Prevention Knowledge among Non-Treatment-Seeking Individuals with Opioid Use Disorder. J Psychoactive Drugs 49:59-68
Metz, Verena E; Jones, Jermaine D; Manubay, Jeanne et al. (2017) Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. Neuropsychopharmacology 42:1825-1832
Vadhan, Nehal P; Corcoran, Cheryl M; Bedi, Gill et al. (2017) Acute effects of smoked marijuana in marijuana smokers at clinical high-risk for psychosis: A preliminary study. Psychiatry Res 257:372-374
Bachtell, Ryan K; Jones, Jermaine D; Heinzerling, Keith G et al. (2017) Glial and neuroinflammatory targets for treating substance use disorders. Drug Alcohol Depend 180:156-170
Babalonis, Shanna; Haney, Margaret; Malcolm, Robert J et al. (2017) Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend 172:9-13
Cooper, Ziva D; Johnson, Kirk W; Pavlicova, Martina et al. (2016) The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict Biol 21:895-903
Herrmann, Evan S; Cooper, Ziva D; Bedi, Gillinder et al. (2016) Effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a laboratory model of relapse in cannabis users. Psychopharmacology (Berl) 233:2469-78

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