This is Competing Renewal of a currently funded Center Grant, """"""""Treatments for Complex Patients in New Settings."""""""" The San Francisco Treatment Research Center (TRC) now has an integrating focus on nicotine. The center has been productive during the past 4 years with 286 scientific articles either published, under review, or in press. The center structure maintains the potential to expand to other drugs of abuse, and to foster the development of investigators across the addictions. There are two Cores--a Scientific and Administrative core and a Quantitative core, and five components. Two of the projects are clinical trials. In Project 1, a series of hypotheses about the efficacy and effectiveness of usual care, tailored counseling, and Internet counseling for HIV positive smokers are tested. Project 2 tests a series of efficacy and effectiveness hypotheses in a study comparing an intensive smoking treatment for alcohol dependent smokers with unusual treatment. Project 3 is a study of organizational change conducted in the clinics participating in Projects 1 and 2 and in two control clinics. Project 4 is a statistical methods study that relies on past TRC data and data generated by Projects 1 and 2 to better develop Latent Class Growth Modeling (LCGM) in treatment research in the addictions. Project 5 is developmental. It supports the TRC aims of the development of treatment investigators, treatment developmental studies, and continues the involvement across drugs of abuse that has characterized our Center. It has two sections: (1) a pilot study grant program that continues and extends the existing TRC pilot study program for trainees; and (2) a developmental support program that will select, mentor and further develop treatment development studies. Two such studies have been selected for completion during the first half of the funding period. The first is an innovative study of smoking cessation treatment in substance abuse treatment in a large Health Maintenance Organization (HMO). The second is an intervention to treat depressed stimulant abuse patients recruited from medical care settings. One potential study, focusing on treatment linkages for substance using and abusing patients in an HMO mental health setting has been proposed, and others will be developed.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Study Section
Special Emphasis Panel (ZDA1-RXL-E (06))
Program Officer
Grossman, Debra
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University of California San Francisco
Schools of Medicine
San Francisco
United States
Zip Code
Pagano, Anna; Gubner, Noah R; Le, Thao et al. (2018) Differences in tobacco use prevalence, behaviors, and cessation services by race/ethnicity: A survey of persons in addiction treatment. J Subst Abuse Treat 94:9-17
Vogel, Erin A; Rubinstein, Mark L; Prochaska, Judith J et al. (2018) Associations between marijuana use and tobacco cessation outcomes in young adults. J Subst Abuse Treat 94:69-73
Murray, Donna E; Durazzo, Timothy C; Schmidt, Thomas P et al. (2018) Regional cerebral blood flow in opiate dependence relates to substance use and neuropsychological performance. Addict Biol 23:781-795
Schackman, Bruce R; Gutkind, Sarah; Morgan, Jake R et al. (2018) Cost-effectiveness of hepatitis C screening and treatment linkage intervention in US methadone maintenance treatment programs. Drug Alcohol Depend 185:411-420
Gubner, Noah R; Thrul, Johannes; Kelly, Oona A et al. (2018) Young adults report increased pleasure from smoking cigarettes when drinking alcohol but not when using marijuana. Addict Res Theory 26:71-76
Newville, Howard; Sorensen, James L; Hatch-Maillette, Mary et al. (2018) Temporal Relationship of Sex Risk Behaviors and Substance Use Severity Among Men in Substance Use Treatment. J Sex Res 55:1056-1064
Pagano, Anna; Gubner, Noah; Le, Thao et al. (2018) Cigarette smoking and quit attempts among Latinos in substance use disorder treatment. Am J Drug Alcohol Abuse 44:660-667
Guydish, Joseph; Tajima, Barbara; Le, Thao et al. (2018) Do cigarette graphic warnings encourage smokers to attend a smoking cessation programme: a quasi-experimental study. Tob Control 27:43-49
McKnight, Courtney; Shumway, Martha; Masson, Carmen L et al. (2017) Perceived discrimination among racial and ethnic minority drug users and the association with health care utilization. J Ethn Subst Abuse 16:404-419
Thrul, Johannes; Ramo, Danielle E (2017) Cessation Strategies Young Adult Smokers Use After Participating in a Facebook Intervention. Subst Use Misuse 52:259-264

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