Abstract

Cocaine abuse alone, and co-ocurring with heroin dependence, have substantial individual and societal consequences. The Substance Abuse Research Center group, Department of Psychiatry, University of Texas Health Science Center-Houston and the Center for Addiction Research, University of Texas Medical Branch-Galveston, are devoted to development and screening of effective pharmacotherapies. Activities include Scientific/Administrative oversight, and implementation of specific preclinical, human laboratory, CRC inpatient, and Treatment Research Clinic outpatient studies. The themes include medication screening and development, specification of intervention points in disease course (ongoing v abstinence), and delineation of optimal medications alone and in combination. The research and clinical activity include a substantial interdisciplinary training component.
The aims will be accomplished through four component projects listed below: 1. Scientific Project-Cocaine/Heroin: Pharmacotherapy Dosing Regimens. 2. Scientific Project-Screening Medications for Cocaine Cessation and Relapse Prevention. 3. Scientific Project-lmpulsivity, Brain Function &Substance Abuse Treatment. 4. Scientific Project-Drug Effects on Oral cocaine-Reinforced Behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA009262-15
Application #
7626828
Study Section
Special Emphasis Panel (ZDA1-RXL-E (03))
Program Officer
Bough, Kristopher J
Project Start
1997-09-01
Project End
2010-07-31
Budget Start
2009-05-01
Budget End
2010-07-31
Support Year
15
Fiscal Year
2009
Total Cost
$2,766,981
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

D'Souza MA, Johann M; Wardle PhD, Margaret; Green PhD, Charles E et al. (2018) Resting Heart Rate Variability: Exploring Associations With Symptom Severity in Adults With Substance Use Disorders and Posttraumatic Stress. J Dual Diagn :1-6
Vujanovic, Anka A; Wardle, Margaret C; Bakhshaie, Jafar et al. (2018) Distress tolerance: Associations with trauma and substance cue reactivity in low-income, inner-city adults with substance use disorders and posttraumatic stress. Psychol Addict Behav 32:264-276
Miller, William R; Fox, Robert G; Stutz, Sonja J et al. (2018) PPAR? agonism attenuates cocaine cue reactivity. Addict Biol 23:55-68
Vujanovic, Anka A; Smith, Lia J; Green, Charles E et al. (2018) Development of a novel, integrated cognitive-behavioral therapy for co-occurring posttraumatic stress and substance use disorders: A pilot randomized clinical trial. Contemp Clin Trials 65:123-129
Ma, Liangsuo; Steinberg, Joel L; Wang, Qin et al. (2017) A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects. Drug Alcohol Depend 173:39-46
Schmitz, Joy M; Green, Charles E; Hasan, Khader M et al. (2017) PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial. Addiction 112:1861-1868
Wardle, Margaret C; Vincent, Jessica N; Suchting, Robert et al. (2017) Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder. J Subst Abuse Treat 72:32-39
Ahn, Woo-Young; Ramesh, Divya; Moeller, Frederick Gerard et al. (2016) Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence. Front Psychiatry 7:34
Azadeh, Shabnam; Hobbs, Brian P; Ma, Liangsuo et al. (2016) Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage 125:813-824
Sharma, Jyoti; Rathnayaka, Nuvan; Green, Charles et al. (2016) Bradycardia as a Marker of Chronic Cocaine Use: A Novel Cardiovascular Finding. Behav Med 42:1-8

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