Relapse to drug use following periods of abstinence is a significant impediment in the long-termtreatment of cocaine dependence. Environmental stimuli or contexts previously associated with drug use orpriming doses of the abused drug can initiate relapse to compulsive drug-seeking and drug-takingbehaviors. The Animal Core B will provide all of the experimental subjects for every project in theNeurobiology of Addiction Research Center (NARC) that involves the use of the self-administration andrelapse model in rats. Rats will be catheterized and trained to self-administer intravenous (i.v.) cocaineusing standard schedules of drug reinforcement. After a stable period of self-administration, lever pressingfor drug will be extinguished to criterion, or animals may undergo abstinence. Subjects will then be directedtowards individual NARC projects for brain tissue extraction, electrophysiology, or assessment of behavioralresponding to systemic or site directed manipulations in accordance with the specific aims of each NARCproject.
The aims of Animal Core B can be summarized as:1. Provide experimental subjects to all projects in the NARC that are consistent and satisfy specific criteriawith regards to experience in drug self-administration and in the degree of withdrawal, extinction, and/orabstinence. The Animal Core will insure that subjects will be handled and treated according to allapproved animal use procedures and, in conjunction with vivarium staff, maintain appropriate animalhusbandry.2. Efficiently manage the distribution of animals to the different projects to insure that statistically relevantgroup sizes and group replications are made available to each project in a timely manner.3. Maintain a staff of well-trained technicians to efficiently generate experimental subjects using a balancedgroup design, as well as provide technical assistance to NARC Projects that will involve furtherbehavioral evaluation of drug-seeking behavior.4. Serve as a NARC training center for junior investigators who desire training in self-administration,jugular catheterization, operant conditioning methods, and other related experimental procedures.The NARC Animal Core will serve as the common foundation for all NARC projects. The results fromintegrated studies through the Animal Core will hopefully lead to useful pharmacotherapeutic agents for thetreatment of cocaine abuse and dependence.
|Hanlon, Colleen A; Dowdle, Logan T; Gibson, Nicole B et al. (2018) Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry 8:186|
|Roberts-Wolfe, Douglas; Bobadilla, Ana-Clara; Heinsbroek, Jasper A et al. (2018) Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons. J Neurosci 38:7100-7107|
|Spencer, Sade; Neuhofer, Daniela; Chioma, Vivian C et al. (2018) A Model of ?9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens. Biol Psychiatry 84:601-610|
|Parrilla-Carrero, Jeffrey; Buchta, William C; Goswamee, Priyodarshan et al. (2018) Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. J Neurosci 38:4212-4229|
|Kearney-Ramos, Tonisha E; Lench, Daniel H; Hoffman, Michaela et al. (2018) Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. Sci Rep 8:3253|
|Giannotti, Giuseppe; Barry, Sarah M; Siemsen, Ben M et al. (2018) Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking. J Neurosci 38:8956-8966|
|Siemsen, Ben M; Lombroso, Paul J; McGinty, Jacqueline F (2018) Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats. Addict Biol 23:219-229|
|Spencer, Sade; Garcia-Keller, Constanza; Roberts-Wolfe, Douglas et al. (2017) Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking. Biol Psychiatry 81:616-624|
|Heinsbroek, Jasper A; Neuhofer, Daniela N; Griffin 3rd, William C et al. (2017) Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking. J Neurosci 37:757-767|
|Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2017) Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. Brain Res 1654:34-42|
Showing the most recent 10 out of 180 publications