The establishment of the Medical University of South Carolina (MUSC) SCOR in 2002 provided a critical impetus to engage the research community in more sex and gender-based research. MUSC had strength in translational, interdisciplinary research addictions, but no sex or gender-specific focus. In addition, the SCOR was the first women's health research initiative on the MUSC campus. The visible, campus-wide collaborations of SCOR Investigators, combined with the Institutional support of the SCOR pilot project program have considerably increased sex and gender-based research. Close collaboration with the MUSC BIRCWH program, awarded in 2007, further enhanced campus-wide, interdisciplinary collaborations focused on women's health. We have begun collaborations with SCOR programs at other universities in order to maximize the scientific output from the ORWH investment in the SCOR initiative by sharing resources and combining data. During the renewal period, our core scientific projects will continue to focus on sex and gender differences in the relationship between addiction and stress response using emerging technology in closely aligned clinical and basic science projects. The overarching goals of the center will focus on supporting and Improving the translational scientific collaborations of the core and pilot research projects, catalyzing further growth of interdisciplinary sex and gender-based research on the MUSC campus and creating strategic partnerships to enhance the translation and dissemination of SCOR findings and other relevant research to improve the health of women and girls. Center funding has allowed us to: 1) increase interdisciplinary sex and gender-based research on the MUSC campus, 2) bring together institutional and scientific leadership to form a high visibility operational unit focused on research In women's health, 3) establish infrastructure to support efficient operations, integration, and stability, 4) coalesce a group of senior investigatos to integrate their scientific expertise and research skills to advance sex and gender-based research, 5) attract and train new and junior investigators in sex and gender-based research, 6) support the development and testing of innovative ideas and new technology, and 7) provide a supportive training environment for basic and clinical researchers interested In sex and gender-based research. The next funding period will allow us to build on these accomplishments, expand our research program utilizing innovative techniques and novel compounds, increase cross-SCOR collaborations, enhance outreach and dissemination efforts, and attract new investigators. Our SCOR, with a truly interdisciplinary and translational focus on sex and gender Issues in addictions and stress response, is prepared to work collaboratively with other SCOR colleagues towards the vision, goals, and objectives outlined In the 2010 ORWH Strategic Plan.

Public Health Relevance

The MUSC SCOR coalesces Investigators across different disciplines working closely together to explore sex and gender differences in addictions and the relationship between stress and drug use. This project catalyzes further growth of Interdisciplinary sex and gender-based research on the MUSC campus and creates strategic partnerships to enhance the translation and dissemination of SCOR findings and other relevant research to improve women's health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
3P50DA016511-13S1
Application #
8891612
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Wetherington, Cora Lee
Project Start
2002-09-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Charleston
State
SC
Country
United States
Zip Code
29403
Moran-Santa Maria, Megan M; Sherman, Brian J; Brady, Kathleen T et al. (2018) Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women. Pharmacol Biochem Behav 165:63-69
Kohtz, Amy S; Lin, Belle; Smith, Michael E et al. (2018) Attenuated cocaine-seeking after oxytocin administration in male and female rats. Psychopharmacology (Berl) 235:2051-2063
Moran-Santa Maria, Megan M; Vanderweyen, Davy C; Camp, Christopher C et al. (2018) Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study. Nicotine Tob Res 20:810-818
Sherman, Brian J; Baker, Nathaniel L; Squeglia, Lindsay M et al. (2018) Approach bias modification for cannabis use disorder: A proof-of-principle study. J Subst Abuse Treat 87:16-22
Tomko, Rachel L; Saladin, Michael E; Baker, Nathaniel L et al. (2018) Sex Differences in Subjective and Behavioral Responses to Stressful and Smoking Cues Presented in the Natural Environment of Smokers. Nicotine Tob Res :
Moreland, Angela D; McRae-Clark, Aimee (2018) Parenting outcomes of parenting interventions in integrated substance-use treatment programs: A systematic review. J Subst Abuse Treat 89:52-59
Spencer, Sade; Neuhofer, Daniela; Chioma, Vivian C et al. (2018) A Model of ?9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens. Biol Psychiatry 84:601-610
Melis, Miriam; Frau, Roberto; Kalivas, Peter W et al. (2017) New vistas on cannabis use disorder. Neuropharmacology 124:62-72
Leong, Kah-Chung; Freeman, Linnea R; Berini, Carole R et al. (2017) Oxytocin Reduces Cocaine Cued Fos Activation in a Regionally Specific Manner. Int J Neuropsychopharmacol 20:844-854
Barth, Kelly S; Guille, Constance; McCauley, Jenna et al. (2017) Targeting practitioners: A review of guidelines, training, and policy in pain management. Drug Alcohol Depend 173 Suppl 1:S22-S30

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