The Behavioral Assessment and Medical (BAM) Core is a new component of the competing TMARC renewal, that merges the Clinical Assessment and Laboratory (CAL) and Neuropsychiatric (NP) Cores from the prior funding period to improve resource efficiency. Now comprised of the Neuromedical and Laboratory Unit (NLU) and the Neuropsychiatric Unit (NPU), the BAM Core will extensively contribute to Center objectives by providing to TMARC Projects and Scientific Cores: 1) comprehensive neuromedical and neurobehavioral characterization of human participants, 2) specimen collection/management, and 3) collaboration and training regarding the analyses/interpretation of neuromedical, laboratory, and neurobehavioral data. Standardized neuromedical assessments will focus on aspects of health affected by HIV, METH and aging, including participants'medical and treatment history, neurological functioning, HIV disease staging, and medical comorbidity status (e.g., VACS Index, frailty). Laboratory assessments will include tests for co-infections, clinical lab assays (e.g., hepatic transaminases, hemoglobin), and soluble and cellular biomarkers in cerebrospinal fluid and blood that reflect HIV replication, immune functioning, and oxidative stress. New measures of biologic aging - cell senescence (telomere shortening) and mitochondrial aging (mtDNA injury) are added in support of TMARC's aging theme. The NLU also will provide assays for TMARC's animal projects and support for TMARC's pilot project on cell senescence. The NPU will provide comprehensive neurobehavioral assessments, including neurocognitive abilities, complex frontal systems behaviors (impulsivity/disinhibition, sensation-seeking, and apathy), comorbid psychiatric conditions (mood, ADHD, ASPD, and substance-related), plus key outcomes such as ART adherence, risky behaviors (unsafe sex, drug use, driving), performance-based lADL assessments, independence in real world functioning (e.g., lADLs, employment, health role functioning), psychosocial functioning (social and emotional functioning, quality of life) and support for TMARC's pilot project examining the utility of novel, virtual reality tasks to assess the everyday impact of neurobehavioral impairments due to METH, HIV and aging.

Public Health Relevance

The BAM Core is central to TMARC's major scientific aim of understanding the CNS consequences of METH and HIV within the context of aging. BAM Core data will enable studies investigating the pathogenesis and functional consequences of HIV and METH that may lead to more targeted interventions for reducing the public health impact of these increasingly prevalent conditions across the lifespan.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA026306-06
Application #
8601371
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Stecher, M; Chaillon, A; Eis-Hübinger, A M et al. (2018) Pretreatment human immunodeficiency virus type 1 (HIV-1) drug resistance in transmission clusters of the Cologne-Bonn region, Germany. Clin Microbiol Infect :
Stecher, Melanie; Chaillon, Antoine; Eberle, Josef et al. (2018) Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions - Cologne/Bonn, Munich and Hannover, 1999-2016. Sci Rep 8:6799
Oppenheim, Hannah; Paolillo, Emily W; Moore, Raeanne C et al. (2018) Neurocognitive functioning predicts frailty index in HIV. Neurology 91:e162-e170
Walker, Keenan A; Brown, Gregory G (2018) HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis. J Clin Exp Neuropsychol 40:357-376
Stecher, Melanie; Hoenigl, Martin; Eis-Hübinger, Anna Maria et al. (2018) Hotspots of Transmission Driving the Local Hiv Epidemic in the Cologne-Bonn Region, Germany. Clin Infect Dis :
Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108
Thaney, Victoria E; Kaul, Marcus (2018) Type I Interferons in NeuroHIV. Viral Immunol :
Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2018) Association of antiretroviral therapy with brain aging changes among HIV-infected adults. AIDS 32:2005-2015
Thaney, Victoria E; Sanchez, Ana B; Fields, Jerel A et al. (2018) Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol 24:156-167
Kesby, James P; Chang, Ariel; Markou, Athina et al. (2018) Modeling human methamphetamine use patterns in mice: chronic and binge methamphetamine exposure, reward function and neurochemistry. Addict Biol 23:206-218

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