NEUROIMAGING(Nl)CORE Given the adverse effects of HIV infection (HIV+) and methamphetamine use (METH+) oh brain structure and function, their combined effects, whether additive or synergistic, would be expected to produce a significant brain disorder. Moreover, as treatment of HIV infection has improved longevity and as the large cohort of METH users age, brain changes related to aging and to the comorbidities of aging are likely to contribute to HIV+ and METH+ related alterations in brain structure and function. In particular, age-related cerebrovascular disease might alter cerebral blood flow, potentiate white matter changes and alter gray matter volume. Aging is also likely to exacerbate changes in brain connectivity expected from white matter changes associated with HIV+ and METH+. Whether the aging contribution to changes of brain structure and function is additive or synergistic to that expected from HIV infection or METH use are unknown. This Core proposes to use translational multi-modal imaging to support investigations into the extent to which aging mediates brain changes associated with HIV infection, methamphetamine dependence and their interaction. To support these investigations the Nl Core Resource Objectives are to: (1) provide TMARC investigators with a core set of human and mouse imaging data;(2) provide specialized imaging protocols and advanced image analysis tools to support new directions in emerging imaging technologies;and (3) train investigators in imaging methods. The Nl Core Scientific Objectives are to: (1) investigate the separate and joint brain abnormalities underlying the neuropsychological and functional disabilities of patients with HIV infection and METH use and their interaction with aging;(2) use multimodal imaging methods to link white matter changes seen in METH use and HIV infection to alterations of functional connections among brain centers;(3) use magnetic resonance imaging protocols comparable to those used in human studies to link human imaging findings to imaging findings in mouse models of HIV infection and methamphetamine use.
To understand the combined effects of METH, HIV, and aging on brain injury, the Nl Core will provide advanced brain imaging methods and imaging analysis tools. Animal models of METH, HIV, and aging will also be imaged to better understand the mechanisms of the associated brain injury and how this injury may be prevented or treated.
|Moore, David J; Pasipanodya, Elizabeth C; Umlauf, Anya et al. (2018) Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial. Drug Alcohol Depend 189:154-160|
|MacDuffie, Katherine E; Brown, Gregory G; McKenna, Benjamin S et al. (2018) Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. Neuroimage Clin 20:1044-1052|
|Stecher, M; Chaillon, A; Eis-Hübinger, A M et al. (2018) Pretreatment human immunodeficiency virus type 1 (HIV-1) drug resistance in transmission clusters of the Cologne-Bonn region, Germany. Clin Microbiol Infect :|
|Stecher, Melanie; Chaillon, Antoine; Eberle, Josef et al. (2018) Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions - Cologne/Bonn, Munich and Hannover, 1999-2016. Sci Rep 8:6799|
|Oppenheim, Hannah; Paolillo, Emily W; Moore, Raeanne C et al. (2018) Neurocognitive functioning predicts frailty index in HIV. Neurology 91:e162-e170|
|Walker, Keenan A; Brown, Gregory G (2018) HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis. J Clin Exp Neuropsychol 40:357-376|
|Stecher, Melanie; Hoenigl, Martin; Eis-Hübinger, Anna Maria et al. (2018) Hotspots of Transmission Driving the Local Hiv Epidemic in the Cologne-Bonn Region, Germany. Clin Infect Dis :|
|Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108|
|Thaney, Victoria E; Kaul, Marcus (2018) Type I Interferons in NeuroHIV. Viral Immunol :|
|Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2018) Association of antiretroviral therapy with brain aging changes among HIV-infected adults. AIDS 32:2005-2015|
Showing the most recent 10 out of 148 publications