The persistence of the HIV epidemic is largely fueled by risky drug practices and sexual behaviors related to METH use, but robust and modifiable neurobehavioral predictors of HIV transmission risk behaviors have yet to be identified. Deficient social cognition, which represents problems with understanding and regulating one's own emotions as well as with placing oneself in another's """"""""shoes"""""""" cognitively and emotionally, may negatively impact the ability to safely navigate HIV risk situations that occur in these highly social contexts, especially when decision-making abilities are impaired, such as in the case of persons with comorbid HIV/METH who are vulnerable to frontal systems injury. Given the negative effects of aging on social cognition, older HIV+ adults who use METH may be particulariy vulnerable. Project 3 aims to utilize a 2x2 factorial design in a cohort of 320 individuals (identical to those in PI) to investigate the separate and combined effects of HIV and METH on social cognition, as well as potential modulation of these effects by age. Among the risk groups, the incremental value of social cognition as a predictor of HIV transmission risk behaviors and social functioning will be investigated. This project also aims to examine the neurobehavioral, neurobiological, neuroimaging, and animal model correlates of human social cognition through synergy with other Cores and Projects. We will also relate our findings to those of a proposed pilot study (Pilot Project D in PAD Core) that tests a mouse model of social cognition. A theory-driven model of social cognition will be comprehensively evaluated through integration of emotional and cognitive components, which will be rigorously measured with multiple indices balanced across laboratory performance-based tests and self-report measures. This novel, inclusive approach will fully characterize social cognition in this cohort, as well as its relation to vital daily functioning outcomes, which will likely fill a critically important missing link in the prediction of HIV risk behaviors, allowing for targeted intervention aimed at HIV transmission reduction.
Risky drug use and sexual behaviors are a driving force in the HIV epidemic and typically occur in social contexts. As such the study of social cognition, which allows an individual to understand the emotional and cognitive aspects of social interactions, may help to reduce the HIV transmission rate by identifying those at risk and informing interventions.
|Walker, Keenan A; Brown, Gregory G (2018) HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis. J Clin Exp Neuropsychol 40:357-376|
|Stecher, Melanie; Hoenigl, Martin; Eis-Hübinger, Anna Maria et al. (2018) Hotspots of Transmission Driving the Local Hiv Epidemic in the Cologne-Bonn Region, Germany. Clin Infect Dis :|
|Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108|
|Thaney, Victoria E; Kaul, Marcus (2018) Type I Interferons in NeuroHIV. Viral Immunol :|
|Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2018) Association of antiretroviral therapy with brain aging changes among HIV-infected adults. AIDS 32:2005-2015|
|Thaney, Victoria E; Sanchez, Ana B; Fields, Jerel A et al. (2018) Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol 24:156-167|
|Kesby, James P; Chang, Ariel; Markou, Athina et al. (2018) Modeling human methamphetamine use patterns in mice: chronic and binge methamphetamine exposure, reward function and neurochemistry. Addict Biol 23:206-218|
|Hoenigl, Martin; Jain, Sonia; Moore, David et al. (2018) Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men1. Emerg Infect Dis 24:|
|Moore, David J; Pasipanodya, Elizabeth C; Umlauf, Anya et al. (2018) Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial. Drug Alcohol Depend 189:154-160|
|MacDuffie, Katherine E; Brown, Gregory G; McKenna, Benjamin S et al. (2018) Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. Neuroimage Clin 20:1044-1052|
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