The overall goal of the Penn State Tobacco Center of Regulatory Science (TCORS) is to develop a leading state-of-the-art research and training infrastructure that will inform policy on the regulation of tobacco products. To achieve these goals, the PSTCORS is uniting the resources of the Penn State College of Medicine with the main University Park campus in State College, PA, Harvard University and George Washington University. A number of Penn State's facilities will be utilized to foster innovative research and training including a newly built smoking laboratory, MRI labs, and our NIH-funded Clinical &Translational Science Institute. The TCORS will allow us to add additional expertise, such as a Smoking Biomarkers Core Laboratory that will perform specialized assays for tobacco science for all TCORS. A central theme of our TCORS is the study of tobacco regulatory science in vulnerable (e.g. low socioeconomic status, mental disorders) and minority populations. This will be accomplished through three complementary research projects that share common methodologies, common core multidisciplinary approaches, and common leadership with the overarching aim of relevancy for tobacco regulatory policies. Penn State University recognizes the more general needs of a Centers for Excellence for tobacco regulatory research in general and strongly supports interdisciplinary efforts and diversity in both its research and its training and educational programs. This commitment will be realized through the development of a dedicated educational program for tobacco regulation scholars and a pilot project program that fosters innovative ideas and research methods for testing and studying tobacco harm. The Penn State World Campus will facilitate our efforts in training young scientists in tobacco regulatory research and collaborating with other TCORS. These efforts are designed to sustain the TCORS concept in the future.

Public Health Relevance

Cigarettes constitute 90% of all combustible tobacco smoke products consumed in the United States and are the single most important cause of avoidable diseases. The Penn State TCORS will evaluate the health effects of switching smokers from their usual cigarettes to reduced nicotine cigarettes on nicotine dependence and tobacco harm. If safe and effective, this strategy will have large public health benefits.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA036107-02
Application #
8737836
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Kautz, Mary A
Project Start
2013-09-30
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Hershey
State
PA
Country
United States
Zip Code
17033
Foulds, J; Hobkirk, A; Wasserman, E et al. (2018) Estimation of compliance with exclusive smoking of very low nicotine content cigarettes using plasma cotinine. Prev Med 117:24-29
Chen, Zhao; Fan, Jianqing; Li, Runze (2018) Error Variance Estimation in Ultrahigh-Dimensional Additive Models. J Am Stat Assoc 113:315-327
Li, Runze; Ren, Jian-Jian; Yang, Guangren et al. (2018) Asymptotic Behavior of Cox's Partial Likelihood and its Application to Variable Selection. Stat Sin 28:2713-2731
Veldheer, Susan; Hrabovsky, Shari; Yingst, Jessica et al. (2018) The Use of Self-Directed Relapse Prevention Booklets to Assist in Maintaining Abstinence After a 6-Week Group Smoking Cessation Treatment Program: A Randomized Controlled Trial. Health Educ Behav 45:190-197
Goel, Reema; Bitzer, Zachary T; Reilly, Samantha M et al. (2018) Effect of Charcoal in Cigarette Filters on Free Radicals in Mainstream Smoke. Chem Res Toxicol 31:745-751
Joseph, Sarah; Krebs, Nicolle M; Zhu, Junjia et al. (2018) Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes. Drug Alcohol Depend 187:109-115
Bitzer, Zachary T; Goel, Reema; Reilly, Samantha M et al. (2018) Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols. Free Radic Biol Med 120:72-79
Bold, Krysten W; Sussman, Steve; O'Malley, Stephanie S et al. (2018) Measuring E-cigarette dependence: Initial guidance. Addict Behav 79:213-218
Hobkirk, Andréa L; Nichols, Travis T; Foulds, Jonathan et al. (2018) Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic cigarette use. Brain Res Bull 138:56-63
Goel, Reema; Bitzer, Zachary T; Reilly, Samantha M et al. (2018) Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke. Chem Res Toxicol 31:325-331

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