This competing renewal application requests continuation of a clinical research center engaged in the clinical study of multichannel cochlear implants. The overall goal of the research is to improve the performance of deafened adults and children using cochlear implants. Field trials of different multichannel cochlear implants have resulted in a wide range of performance outcomes among individuals using the same type of implant. The continuous interleaved sampling speech coding algorithm appears to represent the best available speech coding strategy. However, the number of fitting parameters is large. It is hypothesized that outcome can be significantly enhanced by more systematic adjustment of speech processor fitting algorithms. The proposed application will test this hypothesis in 121 postlingually deafened adults and prelingually deafened children previously implanted with multichannel cochlear implants at our center and 70 newly-recruited profoundly deafened adults and children who will be implanted with a new state-of-the-art cochlear implant (CI-24M). The CI- 24M has been designed to precisely monitor residual intracochlear auditory function in different regions of the cochlea and to perform electrophysiologic measures developed by members of the Iowa Cochlear Implant Center. Electrophysiologic and psychophysical measures will be used to define speech coding fitting algorithms to be field tested in clinical trials using this large population. Five research projects, an Administrative Core A and a Patient Care and Technical Support Core B will address the following aims: 1) determine whether individual variables, such as precise intracochlear localization of residual auditory nerve function, can be used to define speech processor fitting parameters; 2) conduct field trials using different speech processor programs to determine the effectiveness of these speech coding strategies on populations that display a wide range of performance; 3) better understand the subject characteristics (ie: physiologic, cognitive, behavioral, and environmental) that influence and are predictive of outcome with a cochlear implant to develop models that can be used select the most appropriate hearing rehabilitation strategy for an individual; 4) continue longitudinal studies aimed at understanding the effect that age at implantation has on development of speech perception, speech production, language, and sign in a population of prelingually deafened children; 5) determine if a structured listening protocol with a broad range of musical stimuli can enhance user satisfaction and consequently quality of life; 6) determine preoperatively which ear should receive a cochlear implant; and 7) measure the binaural effects of cochlear implants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
2P50DC000242-11
Application #
2125230
Study Section
Special Emphasis Panel (ZDC1-SRB-N (26))
Project Start
1985-09-09
Project End
2000-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Iowa
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Shearer, A Eliot; Tejani, Viral D; Brown, Carolyn J et al. (2018) In Vivo Electrocochleography in Hybrid Cochlear Implant Users Implicates TMPRSS3 in Spiral Ganglion Function. Sci Rep 8:14165
Adunka, Oliver F; Gantz, Bruce J; Dunn, Camille et al. (2018) Minimum Reporting Standards for Adult Cochlear Implantation. Otolaryngol Head Neck Surg 159:215-219
Smith, Nicholas A; McMurray, Bob (2018) Temporal Responsiveness in Mother-Child Dialogue: A Longitudinal Analysis of Children with Normal Hearing and Hearing Loss. Infancy 23:410-431
Wu, Yu-Hsiang; Stangl, Elizabeth; Chipara, Octav et al. (2018) Characteristics of Real-World Signal to Noise Ratios and Speech Listening Situations of Older Adults With Mild to Moderate Hearing Loss. Ear Hear 39:293-304
Gantz, Bruce J; Dunn, Camille C; Oleson, Jacob et al. (2018) Acoustic plus electric speech processing: Long-term results. Laryngoscope 128:473-481
Kim, Jeong-Seo; Tejani, Viral D; Abbas, Paul J et al. (2018) Postoperative Electrocochleography from Hybrid Cochlear Implant users: An Alternative Analysis Procedure. Hear Res 370:304-315
Goman, Adele M; Dunn, Camille C; Gantz, Bruce J et al. (2018) PREVALENCE OF POTENTIAL HYBRID AND CONVENTIONAL COCHLEAR IMPLANT CANDIDATES BASED ON AUDIOMETRIC PROFILE. Otol Neurotol 39:515-517
Bonnard, Damien; Schwalje, Adam; Gantz, Bruce et al. (2018) Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users. Hear Res 367:223-230
Pimperton, Hannah; Walker, Elizabeth A (2018) Word Learning in Children With Cochlear Implants: Examining Performance Relative to Hearing Peers and Relations With Age at Implantation. Ear Hear 39:980-991
McMurray, Bob; Ellis, Tyler P; Apfelbaum, Keith S (2018) How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs. Ear Hear :

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