Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY - OVERVIEW Hearing loss is a pervasive problem and, according to statistics from the NIDCD/NIH website, it is estimated that it affects nearly 37.5 million Americans aged 18 years and older. While remediation with hearing aids and cochlear implants has assisted those with moderate to profound loss, noise interferes with the ability to understand speech. Our research has identified the important advantage of combining acoustic+electric speech processing (A+E) to facilitate improved hearing in noise. Application of A+E processing has improved outcomes of cochlear implants in quiet and noise, but there is significant individual variability in outcome measures among subjects. To address these issues, this application requests continuation of the Iowa Cochlear Implant Clinical Research Center. In this proposal we will investigate hearing and auditory perception using studies that explore the mechanisms of electrical, acoustic, and A+E hearing from the auditory periphery to the cortex, including measures of cortical (re)organization and higher order language processing. Equally important, we also explore human ecology?factors in the person and in the environment that can mediate or impede successful communication and can be modified by A+E speech processing. Our overarching goal of this competitive renewal is to apply basic and cognitive neuroscience methodologies to assist us in addressing these fundamental questions about how individuals use both acoustic and electric auditory information. Four research projects, Human Ecology, Peripheral Electrophysiology, Central Auditory Integration and Cognitive Dynamics of Language Processing, an administrative and patient care/technical support cores are proposed. The overall objectives are to examine the impact that A+E processing function has on real-life socialization, cognition and quality of life issues, and to evaluate auditory processing from the periphery to cortical and higher level processing. We plan to study 200 newly implanted adult subjects with A+E hearing preservation implants, 50 subjects that use a hearing aid, 50 normal hearing subjects, and a combination of 300 previously implanted subjects with A+E, bimodal or single CIs that participate in our research registry. The four research projects are highly integrated and depend on data from each other to answer the experimental questions proposed.

Public Health Relevance

Gantz, Bruce J. PROJECT NARRATIVE - OVERVIEW This research has the potential to develop a better understanding how the brain processes speech and noise and impacts higher level language processing. Real-world measures of hearing in daily environments and the impact on social interactions and cognitive dynamics with A+E processing over time might allow expanding this technology to those with more residual hearing if significant advantages are identified.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Specialized Center (P50)
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Study Section
Special Emphasis Panel (ZDC1)
Program Officer
King, Kelly Anne
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University of Iowa
Schools of Medicine
Iowa City
United States
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Bonnard, Damien; Schwalje, Adam; Gantz, Bruce et al. (2018) Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users. Hear Res 367:223-230
Pimperton, Hannah; Walker, Elizabeth A (2018) Word Learning in Children With Cochlear Implants: Examining Performance Relative to Hearing Peers and Relations With Age at Implantation. Ear Hear 39:980-991
McMurray, Bob; Ellis, Tyler P; Apfelbaum, Keith S (2018) How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs. Ear Hear :
McMurray, Bob; Danelz, Ani; Rigler, Hannah et al. (2018) Speech categorization develops slowly through adolescence. Dev Psychol 54:1472-1491
Klein, Kelsey E; Wu, Yu-Hsiang; Stangl, Elizabeth et al. (2018) Using a Digital Language Processor to Quantify the Auditory Environment and the Effect of Hearing Aids for Adults with Hearing Loss. J Am Acad Audiol 29:279-291
Roembke, Tanja C; Wiggs, Kelsey K; McMurray, Bob (2018) Symbolic flexibility during unsupervised word learning in children and adults. J Exp Child Psychol 175:17-36
Roland Jr, J Thomas; Gantz, Bruce J; Waltzman, Susan B et al. (2018) Long-term outcomes of cochlear implantation in patients with high-frequency hearing loss. Laryngoscope 128:1939-1945
Shearer, A Eliot; Tejani, Viral D; Brown, Carolyn J et al. (2018) In Vivo Electrocochleography in Hybrid Cochlear Implant Users Implicates TMPRSS3 in Spiral Ganglion Function. Sci Rep 8:14165
Adunka, Oliver F; Gantz, Bruce J; Dunn, Camille et al. (2018) Minimum Reporting Standards for Adult Cochlear Implantation. Otolaryngol Head Neck Surg 159:215-219
Smith, Nicholas A; McMurray, Bob (2018) Temporal Responsiveness in Mother-Child Dialogue: A Longitudinal Analysis of Children with Normal Hearing and Hearing Loss. Infancy 23:410-431

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