Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY ? PROJECT 3 The most important deficit faced by people with hearing impairment is understanding acoustic information? particularly speech?in noisy real-world environments. The central goal of this project is to understand the cognitive and neural bases of hearing impaired listeners' abilities to detect complex auditory objects in simulations of noisy real-life environments. Work on normal hearing listeners has identified fundamental cognitive and cortical mechanisms for perceiving auditory objects in noisy backgrounds, and there are established cortical mechanisms for perceiving of speech in noise. In both cases mechanisms in auditory cortex are active during the abstraction of complex objects from noisy backgrounds, and provide input into networks that allow further perceptual, attentional and semantic analysis. These brain networks have not yet been characterized in hearing impaired listeners, and it is not clear if auditory object detection contributes to speech perception in a way that cannot be predicted by peripheral hearing alone.
Aim 1 applies a new measure of the ability to detect complex (non-speech) auditory objects in noise, and relates this to more standard speech in noise perception in a range of hearing impaired listeners. This is done to determine whether of speech in noise in hearing impaired listeners depends on mechanisms for cross-frequency grouping and examine how that dependence differs in patients with impaired acoustic hearing or a CI.
Aim 2 relates brain activation (measured with high density EEG) to performance on these two tasks and measures of peripheral auditory function to identify differences in cortical activation in impaired listeners that are not solely a function of their poor peripheral input.
Aim 3 conducts a longitudinal study to examine changes in the cortical systems for detecting generic auditory objects and speech in noise. We examine the same patients before implantation and 1, 3, 6 and 24 months post implantation using a combination of EEG, Positon Emission Tomography, (to achieve spatially precise measure of cortical activation)and behavioral measures. This will determine how the abilities to detect complex objects and speech in background noise?and the neural substrates that support these abilities?changes with experience with a hearing device.

Public Health Relevance

Project Narrative The central aim of this project is to understand the cognitive and neural bases of hearing impaired listeners? ability to detect complex auditory objects in noisy environments, arguably the most important deficit faced by such listeners. This understanding will help improve cochlear implantation criteria, refine signal processing strategies, develop new outcome measures, and identify the cause of poor outcomes when they lie in cognitive or neural processing rather than in the auditory input. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Specialized Center (P50)
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Special Emphasis Panel (ZDC1)
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University of Iowa
Iowa City
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Bonnard, Damien; Schwalje, Adam; Gantz, Bruce et al. (2018) Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users. Hear Res 367:223-230
Pimperton, Hannah; Walker, Elizabeth A (2018) Word Learning in Children With Cochlear Implants: Examining Performance Relative to Hearing Peers and Relations With Age at Implantation. Ear Hear 39:980-991
McMurray, Bob; Ellis, Tyler P; Apfelbaum, Keith S (2018) How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs. Ear Hear :
McMurray, Bob; Danelz, Ani; Rigler, Hannah et al. (2018) Speech categorization develops slowly through adolescence. Dev Psychol 54:1472-1491
Klein, Kelsey E; Wu, Yu-Hsiang; Stangl, Elizabeth et al. (2018) Using a Digital Language Processor to Quantify the Auditory Environment and the Effect of Hearing Aids for Adults with Hearing Loss. J Am Acad Audiol 29:279-291
Roembke, Tanja C; Wiggs, Kelsey K; McMurray, Bob (2018) Symbolic flexibility during unsupervised word learning in children and adults. J Exp Child Psychol 175:17-36
Roland Jr, J Thomas; Gantz, Bruce J; Waltzman, Susan B et al. (2018) Long-term outcomes of cochlear implantation in patients with high-frequency hearing loss. Laryngoscope 128:1939-1945
Shearer, A Eliot; Tejani, Viral D; Brown, Carolyn J et al. (2018) In Vivo Electrocochleography in Hybrid Cochlear Implant Users Implicates TMPRSS3 in Spiral Ganglion Function. Sci Rep 8:14165
Adunka, Oliver F; Gantz, Bruce J; Dunn, Camille et al. (2018) Minimum Reporting Standards for Adult Cochlear Implantation. Otolaryngol Head Neck Surg 159:215-219
Smith, Nicholas A; McMurray, Bob (2018) Temporal Responsiveness in Mother-Child Dialogue: A Longitudinal Analysis of Children with Normal Hearing and Hearing Loss. Infancy 23:410-431

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