The Clinical Research Center is supported by two Cores. Core A is the administrative core, which provides administrative support for scheduling subjects and handles purchasing, accounting, and general administrative functions for all projects. Core B is the Human Subjects Core where the primary functions are (1) the recruitment of human subjects for participation in the longitudinal study of age-related hearing loss and in experiments proposed in Projects 1-4;(2) collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DNA) from subjects enrolling in and continuing in the longitudinal study, which covers the past 25 years and the next five years;and (3) coordination of subject schedules for the audiologic and medical test battery, annual evaluations, and longitudinal measures. A goal of the Human Subjects Core is to make efficient use of subjects'testing time and coordinate storage of their data to optimize data access and analyses across projects. The Human Subjects Core is fundamental to the Clinical Research Center, with each of the four scientific projects drawing from and contributing to the human subject database. These cross-sectional and longitudinal data provide a rich and detailed characterization of the changes that occur in the aging peripheral and central auditory systems, which will further define and validate phenotypes of age-related hearing loss and assist in the generation of hypotheses and interpretation of experimental results in all projects.
Age-related hearing loss is a current and growing public health concern that affects communication and quality of life of millions of older adults. The Cores support the administration of the Clinical Research Center and provide key data to meet the goals of developing new diagnostic tests and discovering new methods for prevention and treatment of this high-prevalence communication disorder.
|McRackan, Theodore R; Clinkscales, William B; Ahlstrom, Jayne B et al. (2018) Factors associated with benefit of active middle ear implants compared to conventional hearing aids. Laryngoscope 128:2133-2138|
|Dias, James W; McClaskey, Carolyn M; Harris, Kelly C (2018) Time-Compressed Speech Identification Is Predicted by Auditory Neural Processing, Perceptuomotor Speed, and Executive Functioning in Younger and Older Listeners. J Assoc Res Otolaryngol :|
|Worley, Mitchell L; Schlosser, Rodney J; Soler, Zachary M et al. (2018) Age-related differences in olfactory cleft volume in adults: A computational volumetric study. Laryngoscope :|
|McClaskey, Carolyn M; Dias, James W; Dubno, Judy R et al. (2018) Reliability of Measures of N1 Peak Amplitude of the Compound Action Potential in Younger and Older Adults. J Speech Lang Hear Res 61:2422-2430|
|Vaden Jr, Kenneth I; Matthews, Lois J; Dubno, Judy R (2018) Transient-Evoked Otoacoustic Emissions Reflect Audiometric Patterns of Age-Related Hearing Loss. Trends Hear 22:2331216518797848|
|Simpson, Annie N; Matthews, Lois J; Cassarly, Christy et al. (2018) Time From Hearing Aid Candidacy to Hearing Aid Adoption: A Longitudinal Cohort Study. Ear Hear :|
|Noble, Kenyaria V; Reyzer, Michelle L; Barth, Jeremy L et al. (2018) Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury. Front Mol Neurosci 11:243|
|Simpson, Annie N; Simpson, Kit N; Dubno, Judy R (2018) Healthcare Costs for Insured Older U.S. Adults with Hearing Loss. J Am Geriatr Soc 66:1546-1552|
|Lewis, Morag A; Nolan, Lisa S; Cadge, Barbara A et al. (2018) Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes. BMC Med Genomics 11:77|
|Bologna, William J; Vaden Jr, Kenneth I; Ahlstrom, Jayne B et al. (2018) Age effects on perceptual organization of speech: Contributions of glimpsing, phonemic restoration, and speech segregation. J Acoust Soc Am 144:267|
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