Growing evidence indicates that deficits in attention (defined as selection of one external source of information for further processing) and intention (defined as preparation to respond, including choosing one course of action as opposed to others) accompany aphasia. These deficits may exacerbate language symptoms such as naming difficulty in some instances, and language functions may improve when attention/intention manipulations are applied. Specifically, when some premorbidly right-handed patients with aphasia after left-hemisphere lesion are required to attend to stimuli in their left hemispace or gesture with their left hands, they are better able to formulate and/or understand language. In such cases, it seems likely that attending to stimuli in hemispace contralateral to the intact hemisphere or initiating an action with the hand contralateral to the intact hemisphere, engages intact attention or intention mechanisms, respectively, in that hemisphere which then compensate for dysfunctional mechanisms in the damaged hemisphere. The purpose of this subproject is to develop and apply aphasia treatments designed to recruit attention or intention mechanisms in the intact hemisphere and to engage them in language processing. Treatments will target naming; patients who have chronic difficulty in naming will be studied. In addition to assessing the effectiveness of treatments for individual patients, fMRI will be used to explore whether the effects are accomplished by shifting attention and intention demands to the mechanisms in the non-dominant hemisphere. Broader """"""""functional"""""""" aspects of language will also be assessed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC003888-03
Application #
6593825
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
2002-06-01
Project End
2003-05-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$185,019
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Crosson, Bruce; Moore, Anna Bacon; McGregor, Keith M et al. (2009) Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activity. Brain Lang 111:73-85
Parkinson, Bruce R; Raymer, Anastasia; Chang, Yu-Ling et al. (2009) Lesion characteristics related to treatment improvement in object and action naming for patients with chronic aphasia. Brain Lang 110:61-70
Gopinath, Kaundinya; Crosson, Bruce; McGregor, Keith et al. (2009) Selective detrending method for reducing task-correlated motion artifact during speech in event-related FMRI. Hum Brain Mapp 30:1105-19
Rothi, Leslie J Gonzalez; Fuller, Renee; Leon, Susan A et al. (2009) Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease. J Int Neuropsychol Soc 15:311-22
Conway, Tim; Heilman, Kenneth M; Gopinath, Kaundinya et al. (2008) Neural substrates related to auditory working memory comparisons in dyslexia: an fMRI study. J Int Neuropsychol Soc 14:629-39
Hu, Jing; Lee, Jae-Min; Gao, Jianbo et al. (2008) Assessing a signal model and identifying brain activity from fMRI data by a detrending-based fractal analysis. Brain Struct Funct 212:417-26
Crosson, Bruce (2008) An intention manipulation to change lateralization of word production in nonfluent aphasia: current status. Semin Speech Lang 29:188-200;quiz C-4
Lee, Jae-Min; Hu, Jing; Gao, Jianbo et al. (2008) Discriminating brain activity from task-related artifacts in functional MRI: fractal scaling analysis simulation and application. Neuroimage 40:197-212
Crosson, Bruce; McGregor, Keith; Gopinath, Kaundinya S et al. (2007) Functional MRI of language in aphasia: a review of the literature and the methodological challenges. Neuropsychol Rev 17:157-77
Crosson, Bruce; Fabrizio, Katherine S; Singletary, Floris et al. (2007) Treatment of naming in nonfluent aphasia through manipulation of intention and attention: a phase 1 comparison of two novel treatments. J Int Neuropsychol Soc 13:582-94

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