To investigate the etiology of periodontal diseases, possible mechanisms of tissue destruction, and the effects of therapeutic measures, a series of clinical experiments have been designed in which the interrelationships between composition of the plaque microbiota, immunologic response and potential mediators of local tissue pathology are studied in a patient population with advanced destructive disease. Extensive clinical measurements will be carried out to verify that each patient is in an active state of disease at the time of investigation and to monitor the effectiveness of therapeutic regimens tested. Local levels of administered agent will be assessed by pharmacologic monitoring in order to verify that effective dosage has been achieved. Clinical disease activity will be correlated with parameters measured in the laboratory in order to seek possible laboratory aids to diagnosis. The patient's immunologic response to his or her own microbial populations will be tested. By determining which organisms are eliminated or suppressed by different therapeutic regimens and monitoring disease activity, it is hoped that specific pathogens responsible for active periodontal disease can be identified. These findings should lay the basis of preventive therapy directed toward elimination of specific pathogens. By determining the nature of the host response to resident organisms, it is hoped that a more precise definition of pathogenic mechanisms will be obtained which will direct efforts seeking alternative therapeutic measures. By determining the clinical effect of various forms of periodontal therapy, it is hoped that more rational approaches for treating periodontal disease will be devised. At this time, few definitive tests are known which can be used to guide therapy, or to assess its effect. By thoroughly investigating the multiplicity of interrelated facts which are associated with the periodontal disease process, it is hoped that bases for rational prevention and therapy will be established.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
3P50DE004881-10S1
Application #
3105581
Study Section
NIDR Special Grants Review Committee (DSR)
Project Start
1977-08-01
Project End
1988-03-31
Budget Start
1987-05-01
Budget End
1988-03-31
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Forsyth Institute
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Craig, Ronald G; Yip, Julie K; Mijares, Dindo Q et al. (2003) Progression of destructive periodontal diseases in three urban minority populations: role of clinical and demographic factors. J Clin Periodontol 30:1075-83
Craig, Ronald G; Boylan, Robert; Yip, Julie et al. (2002) Serum IgG antibody response to periodontal pathogens in minority populations: relationship to periodontal disease status and progression. J Periodontal Res 37:132-46
Feres, M; Haffajee, A D; Allard, K et al. (2001) Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. J Clin Periodontol 28:597-609
Craig, R G; Boylan, R; Yip, J et al. (2001) Prevalence and risk indicators for destructive periodontal diseases in 3 urban American minority populations. J Clin Periodontol 28:524-35
Cugini, M A; Haffajee, A D; Smith, C et al. (2000) The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 27:30-6
Ximenez-Fyvie, L A; Haffajee, A D; Socransky, S S (2000) Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. J Clin Periodontol 27:722-32
Ximenez-Fyvie, L A; Haffajee, A D; Socransky, S S (2000) Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 27:648-57
Sakellari, D; Goodson, J M; Kolokotronis, A et al. (2000) Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol 27:53-60
Ximenez-Fyvie, L A; Haffajee, A D; Som, S et al. (2000) The effect of repeated professional supragingival plaque removal on the composition of the supra- and subgingival microbiota. J Clin Periodontol 27:637-47
Socransky, S S; Haffajee, A D; Smith, C et al. (2000) Microbiological parameters associated with IL-1 gene polymorphisms in periodontitis patients. J Clin Periodontol 27:810-8

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