Abstract

A. To enumerate the predominant flora in periodontal pockets of patients with periodontitis and juvenile periodontitis (periodontosis). B. To develop methods for rapid identification and enumeration of pocket organisms with pathogenic potential by immunofluorescence, cultural and functional procedures. C. To determine the antibiotic sensitivity of the predominant flora and of the potentially periodontopathologic flora in periodontal pockets as an aid in the selection of appropriate antibiotics for therapy. D. To monitor changes in pocket flora with therapy as part of longitudinal studies of effectiveness of therapy over a long period of time. E. To monitor development of antibiotic resistance in the oral flora during antibiotic therapy. F. To attempt to eradicate candidate pathogens from the periodontal microflora and to assess the clinical effects of this procedure. G. To carry out taxonomic studies including biochemical, serological, genetic and other procedures as necessary to classify periodontal pathogens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE004898-09
Application #
4692784
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Type
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

LaMonte, Michael J; Williams, AnnaLynn M; Genco, Robert J et al. (2014) Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study. J Periodontol 85:1489-501
LaMonte, Michael J; Hovey, Kathleen M; Millen, Amy E et al. (2014) Accuracy of self-reported periodontal disease in the Women's Health Initiative Observational Study. J Periodontol 85:1006-18
LaMonte, Michael J; Hovey, Kathleen M; Genco, Robert J et al. (2013) Five-year changes in periodontal disease measures among postmenopausal females: the Buffalo OsteoPerio study. J Periodontol 84:572-84
Bole, Christopher; Wactawski-Wende, Jean; Hovey, Kathleen M et al. (2010) Clinical and community risk models of incident tooth loss in postmenopausal women from the Buffalo Osteo Perio Study. Community Dent Oral Epidemiol 38:487-97
Brennan-Calanan, R M; Genco, R J; Wilding, G E et al. (2008) Osteoporosis and oral infection: independent risk factors for oral bone loss. J Dent Res 87:323-7
Brennan, Renee M; Genco, Robert J; Hovey, Kathleen M et al. (2007) Clinical attachment loss, systemic bone density, and subgingival calculus in postmenopausal women. J Periodontol 78:2104-11
Genco, Robert J; Falkner, Karen L; Grossi, Sara et al. (2007) Validity of self-reported measures for surveillance of periodontal disease in two western New York population-based studies. J Periodontol 78:1439-54
Brennan, Renee M; Genco, Robert J; Wilding, Gregory E et al. (2007) Bacterial species in subgingival plaque and oral bone loss in postmenopausal women. J Periodontol 78:1051-61
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2006) Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. J Periodontol 77:808-13
Sojar, Hakimuddin T; Genco, Robert J (2005) Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae. FEMS Immunol Med Microbiol 45:25-30

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