The objective of this study is to characterize the periodontal status in an adult population, as part of the assessment of environmental, microbiological and host response risk factors. We propose that periodontal disease develops secondary to subgingival infection by specific periodontal pathogens transmitted from an exogenous source. However, the importance of environmental factors, facilitating the colonization of the specific microorganisms involved, will be further addressed. The environmental factors to be assessed include demographics, socioeconomic status, oral hygiene, local irritant levels, oral disease, utilization of professional services, habits, medication, and diseases such as diabetes. In addition, life events, daily stress and distress will be assessed to determine their importance as risk factors for development of periodontal disease. We propose to utilize a large group of subjects (approximately 2,500) selected by a random process from an urban/suburban population. The group will be thoroughly examined on a triennial basis to provide information for analyses of, 1) cross-sectional and 2) longitudinal data regarding pertinent clinical, microbiology and host response factors. Data will be analyzed to assess the relative importance of these factors in identifying a risk profile for periodontal disease. A subgroup exhibiting severe periodontal disease culled from the sample at the initial examination, will be monitored every six months by the use of a constant force electronic probe for changes in attachment level. Also, serial standardized periapical radiographs will be taken for radiographic bone mass/density assessments by digitized computer subtraction techniques. These new methodologies will make it possible to assess the progression of periodontal disease and to identify cycles of active and inactive tissue destruction, and to relate environmental, microbiological and host response factors to disease activity. In addition, families of probands with severe periodontal disease will be examined in preparation for detailed studies of the transmission of putative periodontal pathogens. These studies will provide significant new information which will be used to determine a high risk profile for periodontal disease, so that subjects exhibiting this profile can be targeted for interceptive therapies preventing the development of periodontal disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE004898-13
Application #
3875310
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Type
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
LaMonte, Michael J; Williams, AnnaLynn M; Genco, Robert J et al. (2014) Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study. J Periodontol 85:1489-501
LaMonte, Michael J; Hovey, Kathleen M; Millen, Amy E et al. (2014) Accuracy of self-reported periodontal disease in the Women's Health Initiative Observational Study. J Periodontol 85:1006-18
LaMonte, Michael J; Hovey, Kathleen M; Genco, Robert J et al. (2013) Five-year changes in periodontal disease measures among postmenopausal females: the Buffalo OsteoPerio study. J Periodontol 84:572-84
Bole, Christopher; Wactawski-Wende, Jean; Hovey, Kathleen M et al. (2010) Clinical and community risk models of incident tooth loss in postmenopausal women from the Buffalo Osteo Perio Study. Community Dent Oral Epidemiol 38:487-97
Brennan-Calanan, R M; Genco, R J; Wilding, G E et al. (2008) Osteoporosis and oral infection: independent risk factors for oral bone loss. J Dent Res 87:323-7
Brennan, Renee M; Genco, Robert J; Wilding, Gregory E et al. (2007) Bacterial species in subgingival plaque and oral bone loss in postmenopausal women. J Periodontol 78:1051-61
Brennan, Renee M; Genco, Robert J; Hovey, Kathleen M et al. (2007) Clinical attachment loss, systemic bone density, and subgingival calculus in postmenopausal women. J Periodontol 78:2104-11
Genco, Robert J; Falkner, Karen L; Grossi, Sara et al. (2007) Validity of self-reported measures for surveillance of periodontal disease in two western New York population-based studies. J Periodontol 78:1439-54
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2006) Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. J Periodontol 77:808-13
Tezal, Mine; Grossi, Sara G; Genco, Robert J (2005) Is periodontitis associated with oral neoplasms? J Periodontol 76:406-10

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