The long term objectives of the Periodontal Disease Research Center are: a) to identify groups of individuals who are at high risk for development of periodontal disease because of smoking, diabetes, stress/distress, and coping behaviors; b) to develop molecular approaches to antiinfective and antiinflammatory therapy, and to diagnosis of high susceptibility states; and c) to assess the role of growth factors in regenerative therapy.
Aims to achieve these objectives relate to four interdependent projects, two pilot studies, and a support core. Project 1, Risk Factors for Periodontal Disease, proposes longitudinal epidemiologic studies to evaluate the extent to which diabetes, smoking, stress/distress, and coping behaviors influence the incidence and rate of periodontal disease. The temporal sequence of infection, host response, and periodontal destruction, as well as acquisition and transmission of periodontopathic organisms will also be established in high risk individuals. Project 2, Molecular Basis of Periodontal Regeneration, is directed to developing molecular approaches to stimulate regeneration of periodontal tissues, while limiting ankylosis and root resorption. The role of epidermal growth factor receptors in periodontal ligament fibroblast differentiation will be assessed. Growth factors, retinoic acid and its derivatives, and bone morphogenic proteins will be evaluated for their influence on proliferation, migration, and differentiation of progenitor cells in vitro, animal model, and human studies. Project 3, IL-8 and Periodontal Diseases, will investigate the role of IL-8, a lymphokine proposed to be central to modulating periodontal infections. Understanding IL-8 receptor abnormalities which are found in juvenile periodontal disease may provide a marker for susceptibility. Structure/function relationships of IL-8 receptor will provide the basis for development of antiinflammatory antagonists. Project 4, Defensins, Bactenecins and Periodontal Diseases; proposes to evaluate these peptide antimicrobial agents from neutrophil granules. Their critical structure/function relationships will serve in the design of novel antibiotics. Coding sequences of these peptides are candidates for in vivo gene therapy experiments in salivary glands. Pilot Project 1, Neutrophil Function in Severe Periodontitis Patients, focuses on assessing how and to what extent neutrophils in high risk patients who are diabetic and/or smoke, are compromised. Pilot Project 2, In Vivo Gene Transfer Experiments in Rat Salivary Glands, is designed to develop adenovirus constructs with potential for in vivo gene transfer into salivary glands. Expression of genetically transferred antimicrobial and antiadherence products in saliva may interfere with development or progression of oral infections. The results of these integrated Center studies, combining molecular biological and population-based clinical studies will be applied to reduction of tooth loss, edentulousness, and periodontal disease in high risk populations and minorities; goals in concert with the objectives of """"""""Healthy People: 2000.""""""""

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
2P50DE004898-16
Application #
3105592
Study Section
Special Emphasis Panel (SRC (03))
Project Start
1977-09-20
Project End
1998-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
16
Fiscal Year
1993
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Type
Schools of Dentistry
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
LaMonte, Michael J; Williams, AnnaLynn M; Genco, Robert J et al. (2014) Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study. J Periodontol 85:1489-501
LaMonte, Michael J; Hovey, Kathleen M; Millen, Amy E et al. (2014) Accuracy of self-reported periodontal disease in the Women's Health Initiative Observational Study. J Periodontol 85:1006-18
LaMonte, Michael J; Hovey, Kathleen M; Genco, Robert J et al. (2013) Five-year changes in periodontal disease measures among postmenopausal females: the Buffalo OsteoPerio study. J Periodontol 84:572-84
Bole, Christopher; Wactawski-Wende, Jean; Hovey, Kathleen M et al. (2010) Clinical and community risk models of incident tooth loss in postmenopausal women from the Buffalo Osteo Perio Study. Community Dent Oral Epidemiol 38:487-97
Brennan-Calanan, R M; Genco, R J; Wilding, G E et al. (2008) Osteoporosis and oral infection: independent risk factors for oral bone loss. J Dent Res 87:323-7
Brennan, Renee M; Genco, Robert J; Wilding, Gregory E et al. (2007) Bacterial species in subgingival plaque and oral bone loss in postmenopausal women. J Periodontol 78:1051-61
Brennan, Renee M; Genco, Robert J; Hovey, Kathleen M et al. (2007) Clinical attachment loss, systemic bone density, and subgingival calculus in postmenopausal women. J Periodontol 78:2104-11
Genco, Robert J; Falkner, Karen L; Grossi, Sara et al. (2007) Validity of self-reported measures for surveillance of periodontal disease in two western New York population-based studies. J Periodontol 78:1439-54
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2006) Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. J Periodontol 77:808-13
Sojar, Hakimuddin T; Genco, Robert J (2005) Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae. FEMS Immunol Med Microbiol 45:25-30

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