Abstract

1) To study bacterial interrelationships in an in vivo gnotobiotic animal model of the bacteria Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. 2) To determine the effects of sequential inoculation of the colonization of bacteria and subsequent production of caries. 3) To determine the effect on the production of caries of mono- and of multiple inoculation. 4) To determine the effects of modulation of the host response to one or more of the bacteria on the colonization and production of caries. 5) To compare the results obtained in the in vivo model with those obtained in the in vitro experiment (Clarkson, R01 Root caries study in vitro).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE007010-04
Application #
3940125
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Levy, S M; Maurice, T J; Jakobsen, J R (1993) Feeding patterns, water sources and fluoride exposures of infants and 1-year-olds. J Am Dent Assoc 124:65-9
Levy, S M; Jensen, M E (1990) A clinical evaluation of the restoration of root surface caries. Spec Care Dentist 10:156-60
Ekstrand, J; Spak, C J (1990) Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. J Bone Miner Res 5 Suppl 1:S53-61
Spak, C J; Sjostedt, S; Eleborg, L et al. (1990) Studies of human gastric mucosa after application of 0.42% fluoride gel. J Dent Res 69:426-9
Almqvist, H; Wefel, J S; Lagerlof, F (1990) Root hard-tissue demineralization rate measured by 125I absorptiometry: comparison with lesion-depth measurements. J Dent Res 69:1519-21
Bowden, G H; Ekstrand, J; McNaughton, B et al. (1990) Association of selected bacteria with the lesions of root surface caries. Oral Microbiol Immunol 5:346-51
Ekstrand, J; Spak, C J; Vogel, G (1990) Pharmacokinetics of fluoride in man and its clinical relevance. J Dent Res 69 Spec No:550-5;discussion 556-7
Oliveby, A; Twetman, S; Ekstrand, J (1990) Diurnal fluoride concentration in whole saliva in children living in a high- and a low-fluoride area. Caries Res 24:44-7
Oliveby, A; Lagerlof, F; Ekstrand, J et al. (1989) Studies on fluoride excretion in human whole saliva and its relation to flow rate and plasma fluoride levels. Caries Res 23:243-6
Ekstrand, J (1989) Fluoride intake in early infancy. J Nutr 119:1856-60

Showing the most recent 10 out of 23 publications