Abstract

The Tissue Procurement Core will organize the retrieval of human tissues for RCOB research. specimens of human oral mucosa will be obtained from the clinics of the Departments of Periodontics and Oral Surgery. Tissues removed during routine treatment for periodontal diseases include variously inflamed human gingiva and granulation tissue. In addition, specimens of normal human oral mucosa and periodontal ligament which adhere to extracted teeth will be obtained. Samples of venous blood and of gingival crevicular fluid will be obtained from consenting patients as needed. Pertinent patient information will be collected from existing records and supplied to investigators as needed. The core faculty and staff will interact closely with, and serve as a liaison between, RCOB investigators and the faculty and staff of the Departments of Oral Surgery and Periodontics. The Core will also interact closely with the General Tissue Procurement Facility on campus operated by the Department of Pathology and the Comprehensive Cancer Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE008228-07
Application #
3753705
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Windsor, L Jack; Steele, Darin L (2010) Expression of recombinant matrix metalloproteinases in Escherichia coli. Methods Mol Biol 622:67-81
Katz, Jannet; Yang, Qiu-Bo; Zhang, Ping et al. (2002) Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun 70:2512-8
Smith, P D; Smythies, L E; Mosteller-Barnum, M et al. (2001) Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol 167:2651-6
Aznavoorian, S; Moore, B A; Alexander-Lister, L D et al. (2001) Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res 61:6264-75
Hirschfeld, M; Weis, J J; Toshchakov, V et al. (2001) Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69:1477-82
Windsor, L J; Steele, D L (2001) Expression of recombinant matrix metalloproteinases in Escherichia coli. Methods Mol Biol 151:191-205
Steele, D L; El-Kabbani, O; Dunten, P et al. (2000) Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng 13:397-405
Katz, J; Sambandam, V; Wu, J H et al. (2000) Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infect Immun 68:1441-9
Moore, B A; Aznavoorian, S; Engler, J A et al. (2000) Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts. Biochim Biophys Acta 1502:307-18
Caterina, J J; Shi, J; Kozak, C A et al. (2000) Characterization, expression analysis and chromosomal mapping of mouse matrix metalloproteinase-19 (MMP-19). Mol Biol Rep 27:73-9

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