Abstract

The Tissue Procurement Core will organize the retrieval of human tissues for RCOB research. specimens of human oral mucosa will be obtained from the clinics of the Departments of Periodontics and Oral Surgery. Tissues removed during routine treatment for periodontal diseases include variously inflamed human gingiva and granulation tissue. In addition, specimens of normal human oral mucosa and periodontal ligament which adhere to extracted teeth will be obtained. Samples of venous blood and of gingival crevicular fluid will be obtained from consenting patients as needed. Pertinent patient information will be collected from existing records and supplied to investigators as needed. The core faculty and staff will interact closely with, and serve as a liaison between, RCOB investigators and the faculty and staff of the Departments of Oral Surgery and Periodontics. The Core will also interact closely with the General Tissue Procurement Facility on campus operated by the Department of Pathology and the Comprehensive Cancer Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE008228-09
Application #
5210115
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Windsor, L Jack; Steele, Darin L (2010) Expression of recombinant matrix metalloproteinases in Escherichia coli. Methods Mol Biol 622:67-81
Katz, Jannet; Yang, Qiu-Bo; Zhang, Ping et al. (2002) Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun 70:2512-8
Smith, P D; Smythies, L E; Mosteller-Barnum, M et al. (2001) Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol 167:2651-6
Aznavoorian, S; Moore, B A; Alexander-Lister, L D et al. (2001) Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res 61:6264-75
Hirschfeld, M; Weis, J J; Toshchakov, V et al. (2001) Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69:1477-82
Windsor, L J; Steele, D L (2001) Expression of recombinant matrix metalloproteinases in Escherichia coli. Methods Mol Biol 151:191-205
Caterina, J J; Shi, J; Kozak, C A et al. (2000) Characterization, expression analysis and chromosomal mapping of mouse matrix metalloproteinase-19 (MMP-19). Mol Biol Rep 27:73-9
Foster, K W; Frost, A R; McKie-Bell, P et al. (2000) Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res 60:6488-95
Caterina, J; Shi, J; Sun, X et al. (2000) Cloning, characterization, and expression analysis of mouse enamelysin. J Dent Res 79:1697-703
Caterina, J J; Yamada, S; Caterina, N C et al. (2000) Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation. J Biol Chem 275:26416-22

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