The Center is designed to conduct research and develop new materials for use in dentistry and the health sciences using a multidisciplinary approach by dental materials scientists, materials engineering scientists, and biological scientists. The research will focus on four main areas: (1) novel elastomers to be used for extra oral maxillofacial prostheses and permanently soft complete denture liners, (2) new rigid polymer-ceramic composites for tooth restorative applications having long term wear resistance and in vitro methods to simulate and evaluate the aging of these composites in the oral environment, (3) advanced ceramics for esthetic crowns and bridges with major increases in toughness and fracture resistance, and (4) valid in vitro and animal tests to predict the short and long term biocompatibility of dental materials used for applications ranging from implants to restorative materials. The research projects of the Center will be directed by five faculty members from the dental biomaterials area, four from the materials science and engineering area, one from experimental oral pathology and four from oral biology. These faculty will be assisted by research staff, postdoctoral researchers and graduate research assistants and thus the Center will serve as a training area for future primary researchers in biomaterials. The Center will be administered by the Director and Co-Director with advice from an Internal Review Board having a broad scientific and industrial perspective. The Center will serve as the focus of biomaterials at the University as well as nationally and internationally as a result of interactions with graduate programs, seminars, conferences, and visiting professor and scholar programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
1P50DE009296-01
Application #
3105775
Study Section
(SRC)
Project Start
1989-09-29
Project End
1994-09-28
Budget Start
1989-09-29
Budget End
1990-09-28
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Nakamoto, Tetsuji; Romanenko, Victor G; Takahashi, Atsushi et al. (2008) Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland. Am J Physiol Cell Physiol 294:C810-9
Rasmussen, Stephen T; McLaren, Charles I; O'Brien, William J (2004) The effect of cesium-containing leucite additions on the thermal and mechanical properties of two leucite-based porcelains. J Biomed Mater Res B Appl Biomater 69:195-204
Costa, C A; Edwards, C A; Hanks, C T (2001) Cytotoxic effects of cleansing solutions recommended for chemical lavage of pulp exposures. Am J Dent 14:25-30
Mohsen, N M; Craig, R G; Filisko, F E (2001) The effects of moisture on the dielectric relaxation of urethane dimethacrylate polymer and composites. J Oral Rehabil 28:376-92
Mohsen, N M; Craig, R G; Filisko, F E (2000) The effects of different additives on the dielectric relaxation and the dynamic mechanical properties of urethane dimethacrylate. J Oral Rehabil 27:250-68
Costa, C A; Vaerten, M A; Edwards, C A et al. (1999) Cytotoxic effects of current dental adhesive systems on immortalized odontoblast cell line MDPC-23. Dent Mater 15:434-41
Sun, Z L; Fang, D N; Wu, X Y et al. (1998) Expression of dentin sialoprotein (DSP) and other molecular determinants by a new cell line from dental papillae, MDPC-23. Connect Tissue Res 37:251-61
Hanks, C T; Fang, D; Sun, Z et al. (1998) Dentin-specific proteins in MDPC-23 cell line. Eur J Oral Sci 106 Suppl 1:260-6
Rasmussen, S T; Groh, C L; O'Brien, W J (1998) Stress induced phase transformation of a cesium stabilized leucite porcelain and associated properties. Dent Mater 14:202-11
O'Brien, W J; Boenke, K M; Linger, J B et al. (1998) Cerium oxide as a silver decolorizer in dental porcelains. Dent Mater 14:365-9

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