Abstract

The Biostatistics Core Facility for the Oral Cancer Research Center will provide services and collaboration to all investigators. This will enhance each project, better ensure the most effective design of studies, prospective data collection on all eligible patients, computer data base management and use of statistical methods for integration and analyses of data. The Core will: 1) provide the statistical design of all projects, 2) provide prospective data collection and data entry for all identified patients with histologically confirmed squamous cell carcinoma of the oral cavity and pharynx, and quality assurance of data, 3) provide a coordinated computer database management system to obtain and integrate data from all projects and cores, 4) provide biostatistical analyses of hypotheses, 5) work collaboratively with investigators to develop and prioritize multivariate, across project analyses, and 6) to develop and adapt statistical methods for analyses of multiple biologic markers in aggressive vs. non-aggressive skin cancer research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE011906-05
Application #
6352863
Study Section
Project Start
2000-08-01
Project End
2002-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Wang, Heng; Hicks, John; Khanbolooki, Parham et al. (2003) Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene. Am J Pathol 163:453-64
Gonzalez, Hernan E; Gujrati, Manu; Frederick, Mitchell et al. (2003) Identification of 9 genes differentially expressed in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129:754-9
Jayakumar, Arumugam; Kang, Ya'an; Frederick, Mitchell J et al. (2003) Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys 409:367-74
Chun, Kyung-Hee; Benbrook, Doris M; Berlin, K Darrell et al. (2003) The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway. Cancer Res 63:3826-32
Higuchi, Eisaku; Chandraratna, Roshantha A S; Hong, Waun K et al. (2003) Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. Oncogene 22:4627-35
Liu, Yanna; Li, Jun Z; Yuan, Xiao H et al. (2002) An AP-1 binding site mutation in HPV-16 LCR enhances E6/E7 promoter activity in human oral epithelial cells. Virus Genes 24:29-37
Yan, Chunhong; Wang, Heng; Boyd, Douglas D (2002) ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem 277:10804-12
El-Naggar, Adel K; Kim, Hyung W; Clayman, Gary L et al. (2002) Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classification. Oncogene 21:8206-19
Shin, M; Yan, C; Boyd, D (2002) An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. Biochim Biophys Acta 1589:311-6
Hayashi, K; Yokozaki, H; Naka, K et al. (2001) Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines. Jpn J Cancer Res 92:42-50

Showing the most recent 10 out of 57 publications