Abstract

The Biostatistics Core is designed to provide statistical and epidemiologic expertise and data management services to support the research projects of the Oral Cancer Research Center (OCRC). The extensive interactions among projects in the OCRC and quantitative evaluation of each specific project require cohesive statistical support and the establishment of this core facility.
The specific aims of the Biostatistics Core are to: (1) coordinate statistical activities in the OCRC to ensure that investigators have ready access to statistical consultation and support; (2) provide statistical and epidemiologic expertise in study design including research plan, sample size determination and data collection form design; (3) develop and manage oral cancer related research databases to serve as a multidisciplinary research resource for project investigators; and (4) provide statistical analysis for OCRC projects using the most up-to-date statistical methodologies and computing facilities. An important feature of our Biostatistics Core is the collaboration of a senior epidemiologist, experienced in cancer epidemiology and in molecular medicine, permitting valuable research design input into all the project and into the analytic challenges.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE011910-05
Application #
6354653
Study Section
Project Start
2000-08-01
Project End
2002-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Deng, Wentao; Jin, Ge; Lin, Biing-Yuan et al. (2003) mRNA splicing regulates human papillomavirus type 11 E1 protein production and DNA replication. J Virol 77:10213-26
Broker, T R; Jin, G; Croom-Rivers, A et al. (2001) Viral latency--the papillomavirus model. Dev Biol (Basel) 106:443-51; discussion 452-3, 465-7
Lee, J H; Engler, J A; Collawn, J F et al. (2001) Receptor mediated uptake of peptides that bind the human transferrin receptor. Eur J Biochem 268:2004-12
Balague, C; Noya, F; Alemany, R et al. (2001) Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes. J Virol 75:7602-11
Noya, F; Chien, W M; Broker, T R et al. (2001) p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. J Virol 75:6121-34
Aznavoorian, S; Moore, B A; Alexander-Lister, L D et al. (2001) Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res 61:6264-75
Windsor, L J; Steele, D L (2001) Expression of recombinant matrix metalloproteinases in Escherichia coli. Methods Mol Biol 151:191-205
Foster, K W; Frost, A R; McKie-Bell, P et al. (2000) Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res 60:6488-95
Ma, T; Van Tine, B A; Wei, Y et al. (2000) Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev 14:2298-313
Steele, D L; El-Kabbani, O; Dunten, P et al. (2000) Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng 13:397-405

Showing the most recent 10 out of 17 publications