This Core will serve as a small central unit that provides administrative and communication support for the sub-projects and cores of this Center. This Core will also foster research interactions and communications within this institution and the greater Harvard Medical School research community as well as enable links to other Specialized Centers for Research (SCR) of NIDCR and NIH (including The Lipid MAPS Consortium). An overall goal and function of this Core is to facilitate data sharing networks both within and outside the center for expediting the utilization and translation of findings from this Center's research efforts in oral infectious disease and periodontal inflammation with a focus in resolution of acute inflammation to clinical and basic science arenas. Personnel are described in the justification. This Core will occupy recently renovated office space on the 7th floor of the Thorn Building for Medical Research at Brigham and Women's Hospital. In addition to fully networked PCs, conference room and adjacent bioinformatics work area, the Core is currently equipped with 6 workstations for Net searches, data analysis, and manuscript preparation. This Core will also be responsible for the Center's financial oversight and the supervision of individual grant spending. The Core leader and co-leaders shall monitor scientific progress of sub-projects and scientific Cores to provide scientific guidance and insight to current and emerging clinical challenges, needs, and observations. This Core will provide sub-project investigators with monthly updates of current balances, pending expenditures, and projected estimates of annual expenditures. This Core's personnel will schedule meetings for the Sub-Project and Core Leaders, coordinate the Scientific Advisory Committee agenda and activities, prepare and distribute meeting minutes and reports, and coordinate the annual preparation of progress reports as well as applications. This Core will host and maintain the Center home page / data portal and a new site devoted to this SCR to enhance data sharing and communication between individual sub-projects as well as serve as a centralization site of this Specialized Center for Research's mission and relations to developing institutional activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE016191-05
Application #
7676066
Study Section
Special Emphasis Panel (ZDE1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$119,180
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Van Dyke, T E; Hasturk, H; Kantarci, A et al. (2015) Proresolving nanomedicines activate bone regeneration in periodontitis. J Dent Res 94:148-56
Winkler, Jeremy W; Uddin, Jasim; Serhan, Charles N et al. (2013) Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer. Org Lett 15:1424-7
Gao, Li; Faibish, Dan; Fredman, Gabrielle et al. (2013) Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol 190:689-94
Bartold, P Mark; Van Dyke, Thomas E (2013) Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000 62:203-17
Petasis, Nicos A; Yang, Rong; Winkler, Jeremy W et al. (2012) Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Lett 53:1695-1698
Hasturk, Hatice; Kantarci, Alpdogan; Van Dyke, Thomas E (2012) Paradigm shift in the pharmacological management of periodontal diseases. Front Oral Biol 15:160-76
Hasturk, Hatice; Kantarci, Alpdogan; Van Dyke, Thomas E (2012) Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol 3:118
Schif-Zuck, Sagie; Gross, Nufar; Assi, Simaan et al. (2011) Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. Eur J Immunol 41:366-79
MacManus, Christopher F; Campbell, Eric L; Keely, Simon et al. (2011) Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization. FASEB J 25:1856-64
Serhan, Charles N; Petasis, Nicos A (2011) Resolvins and protectins in inflammation resolution. Chem Rev 111:5922-43

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