The Liver Research Center involves 30 major investigators in 8 departments at the Albert Einstein College of Medicine, and collaborations at 6 other institutions. Our emphasis is to bridge the gap between advances in basic biology and their application to liver physiology and disease processes. Since the Liver Research Center was established and funded in 1977, the program has expanded in space, faculty, projects, administrative and educational efforts, and research funding. The Liver Research Center is now a major interdisciplinary activity at the Albert Einstein College of Medicine. Research efforts focus on mechanisms of liver cell injury and regeneration. Major studies involve effects of hepatitis viruses, metals, drugs, chemicals, parasites and inheritable disorders; collagen deposition and prevention, molecular mechanisms of protein synthesis and viral replication, structural-functional studies, transport at the subcellular and molecular level and hepatic detoxification. Major studies include (1) reo virus and biliary atresia; (2) receptors in normal and regenerating liver; (3) copper toxicity; (4) cDNA probes in study of collagen, ligandin, and HBsAG m RNAs; (5) development of a novel liver cell culture which retains differentiated function, and (6) detection of fibrogenesis. Four core facilities are in operational: Protein Chemistry (Bhargava), Cell Culture (Reid) Morphology (Goldfischer) and Administrative (Arias/Shea). New collaborations have been established with outstanding biophysicists at Bell Labs for NMR studies of liver metabolism. The facilities include 36 well-equipped laboratories, newly renovated 800 sq. ft. Animal Institute, 25-bed Adult Clinical Research Center, Human Heredity Center and Pediatric Liver Registry. Clinical facilities include a 1100-bed general hospital and a 400-bed University Hospital. A large diverse patient population includes many patients with viral, alcoholic, parasitic and inheritable disorders of the liver.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK017702-14
Application #
3105833
Study Section
(SRC)
Project Start
1977-06-01
Project End
1989-05-31
Budget Start
1986-06-01
Budget End
1989-05-31
Support Year
14
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Rogler, C E; Yang, D; Rossetti, L et al. (1994) Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem 269:13779-84
Treichel, U; Paietta, E; Poralla, T et al. (1994) Effects of cytokines on synthesis and function of the hepatic asialoglycoprotein receptor. J Cell Physiol 158:527-34
Weiss, P; Ashwell, G; Morell, A G et al. (1994) Modulation of the asialoglycoprotein receptor in human hepatoma cells: effect of glucose. Hepatology 19:432-9
Yang, D; Alt, E; Rogler, C E (1993) Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers. Cancer Res 53:2020-7
Stockert, R J (1993) Regulation of the human asialoglycoprotein receptor by cAMP. J Biol Chem 268:19540-4
Stockert, R J; Paietta, E; Racevskis, J et al. (1992) Posttranscriptional regulation of the asialoglycoprotein receptor by cGMP. J Biol Chem 267:56-9
Paietta, E; Stockert, R J; Racevskis, J (1992) Alternatively spliced variants of the human hepatic asialoglycoprotein receptor, H2, differ in cellular trafficking and regulation of phosphorylation. J Biol Chem 267:11078-84
Schirmacher, P; Held, W A; Yang, D et al. (1992) Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res 52:2549-56
Min, A D; Goeser, T; Liu, R et al. (1991) Organic anion transport in HepG2 cells: absence of the high-affinity, chloride-dependent transporter. Hepatology 14:1217-23
Wang, H P; Rogler, C E (1991) Topoisomerase I-mediated integration of hepadnavirus DNA in vitro. J Virol 65:2381-92

Showing the most recent 10 out of 31 publications