The purpose of this Center will be to bring together the different expertise and approaches of individuals working primarily outside the renal area to interact with individuals with a nephrology background to focus on mechanisms of glomerular and tubular injury. In particular, the proposal will address the sequences of events leading from initial immune - mediated glomerular injury through formation of the glomerular crescent to sclerosis of the glomerulars. We will further delineate the biology of the normal tubule and its relation to issues pertinent to tubule injury and will examine how tubules are damaged by immunologic and inflammatory mediators, hypoxia and nephrotoxin. The nephrotoxicity of cyclosporin will be investigated at the cellular, tubular and whole animal level, as well as in man. To accomplish these goals, the Center will comprise 17 investigators participating in 11 projects and 3 Cores. A morphology and administrative Core will support all aspects of the Center while the final core will provide the animal model and cell culture support for the Cresentic Nephritis Components of the Center.
| Hato, Takashi; Winfree, Seth; Day, Richard et al. (2017) Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. J Am Soc Nephrol 28:2420-2430 |
| Kikuchi, Masao; Wickman, Larysa; Hodgin, Jeffrey B et al. (2015) Podometrics as a Potential Clinical Tool for Glomerular Disease Management. Semin Nephrol 35:245-55 |
| Yu, Fa-Xing; Zhao, Bin; Guan, Kun-Liang (2015) Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell 163:811-28 |
| Fukuda, Akihiro; Wickman, Larysa T; Venkatareddy, Madhusudan P et al. (2012) Urine podocin:nephrin mRNA ratio (PNR) as a podocyte stress biomarker. Nephrol Dial Transplant 27:4079-87 |
| Fukuda, Akihiro; Wickman, Larysa T; Venkatareddy, Madhusudan P et al. (2012) Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. Kidney Int 81:40-55 |
| Wiggins, Jocelyn E (2012) Aging in the glomerulus. J Gerontol A Biol Sci Med Sci 67:1358-64 |
| Fukuda, Akihiro; Chowdhury, Mahboob A; Venkatareddy, Madhusudan P et al. (2012) Growth-dependent podocyte failure causes glomerulosclerosis. J Am Soc Nephrol 23:1351-63 |
| Chernin, Gil; Vega-Warner, Virginia; Schoeb, Dominik S et al. (2010) Genotype/phenotype correlation in nephrotic syndrome caused by WT1 mutations. Clin J Am Soc Nephrol 5:1655-62 |
| Chernin, Gil; Heeringa, Saskia F; Vega-Warner, Virginia et al. (2010) Adequate use of allele frequencies in Hispanics--a problem elucidated in nephrotic syndrome. Pediatr Nephrol 25:261-6 |
| Kim, Doyeob; Patel, Sanjeevkumar R; Xiao, Hong et al. (2009) The role of PTIP in maintaining embryonic stem cell pluripotency. Stem Cells 27:1516-23 |
Showing the most recent 10 out of 189 publications
