Abstract

Traditionally, anatomy has complemented other disciplines in the study of renal pathophysiology. Today in anatomy, as in other disciplines, state- of-the-art specimen preparation and analysis involve improved methods, reagents and instruments that are complicated and expensive. Renal structure is sensitive to fixatives and perfusion conditions; immunohistochemistry requires dozens of solutions, any of which can confound the staining, expensive microscopies and computers are required for photomicrography and computerized morphometry; ... This Core facility will provide personnel, material, and instrumentation to ensure that high quality morphologic correlation is available for each of the Center projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK039261-10
Application #
5210627
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

He, Wenjuan; Zhang, Min; Zhao, Min et al. (2014) Increased dietary sodium induces COX2 expression by activating NF?B in renal medullary interstitial cells. Pflugers Arch 466:357-367
Fujita, Hiroki; Fujishima, Hiromi; Takahashi, Keiko et al. (2012) SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice. Metabolism 61:1714-24
Zent, Roy; Harris, Raymond (2012) The mammalian kidney. Exp Cell Res 318:v
Riggins, Karen S; Mernaugh, Glenda; Su, Yan et al. (2010) MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res 316:2993-3005
Fujita, Hiroki; Fujishima, Hiromi; Chida, Shinsuke et al. (2009) Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol 20:1303-13
Sparrow, Duncan B; Boyle, Scott C; Sams, Rebecca S et al. (2009) Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia. J Am Soc Nephrol 20:777-86
Zhang, Ming-Zhi; Xu, Jie; Yao, Bing et al. (2009) Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest 119:876-85
Yao, Bing; Harris, Raymond C; Zhang, Ming-Zhi (2009) Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. Hypertension 54:1077-83
Srichai, Manakan B; Hao, Chuanming; Davis, Linda et al. (2008) Apoptosis of the thick ascending limb results in acute kidney injury. J Am Soc Nephrol 19:1538-46
Boyle, Scott; Misfeldt, Andrew; Chandler, Kelly J et al. (2008) Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol 313:234-45

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