Maldevelopment of the kidney and urinary tract accounts for approximately 30% of renal failure in children. Acute renal failure (ARF) is the most frequent kidney-related diagnosis in adult hospitalized patients. The process of regeneration of damaged portions of the nephron following acute renal injury recapitulates the developmental process. A delineation and understanding of the molecular basis of renal organogenesis and regeneration of the nephron following ARF is a prerequisite for developing strategies for treatment and prevention. The rationale for the George M. O'Brien Center at Washington University is to continue funding for a multi disciplinary effort to delineate the molecular basis of renal organogenesis and its abnormalities and regeneration following ARF. The objectives of the Center are: a) to attract new scientific expertise into the study of developmental nephrology and ARF; b) to conduct research that integrates the disciplines of adult and pediatric nephrology, endocrinology, pathology, genetics, cellular and molecular biology and physiology; and c) to extend these basic investigations into areas that will provide the basis for an understanding of the causes for and prevention of specific developmental kidney abnormalities and the treatment of ARF. Pathophysiological processes that will be investigated include maldevelopment of the kidney and ARF, disorders of branching morphogenesis during kidney development and repair, disorders of the glomerular basement membrane and disorders of fluid and electrolyte transport resulting from aberrant maturation of the H+ATPase and Na+-K+-ATPase. The strategy for achieving these objectives is to integrate the efforts of an accomplished group of cellular and molecular-oriented biomedical scientists with interdigitating areas of expertise in the setting of an Institution with formidable resources and a strong research tradition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK045181-10
Application #
6380724
Study Section
Special Emphasis Panel (SRC (01))
Program Officer
Moxey-Mims, Marva M
Project Start
1992-05-01
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2003-04-30
Support Year
10
Fiscal Year
2001
Total Cost
$775,512
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hammerman, Marc R (2004) Applications of organ precursor cell therapy: can lessons from embryonic kidney transplantation be applied to the endocrine pancreas? Curr Opin Nephrol Hypertens 13:23-9
Hammerman, Marc R (2004) Transplantation of embryonic organs - kidney and pancreas. Am J Transplant 4 Suppl 6:14-24
Akimoto, Tetsu; Hammerman, Marc R (2003) Fibroblast growth factor 2 promotes microvessel formation from mouse embryonic aorta. Am J Physiol Cell Physiol 284:C371-7
Rogers, Sharon A; Talcott, Michael; Hammerman, Marc R (2003) Transplantation of pig metanephroi. ASAIO J 49:48-52
Cheng, Hui-Teng; Miner, Jeffrey H; Lin, MeeiHua et al. (2003) Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development 130:5031-42
Rogers, Sharon A; Liapis, Helen; Hammerman, Marc R (2003) Intraperitoneal transplantation of pancreatic anlagen. ASAIO J 49:527-32
Holliday, L S; Welgus, H G; Hanna, J et al. (2003) Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int 72:206-14
Hammerman, Marc R (2003) Therapeutic promise of embryonic kidney transplantation. Nephron Exp Nephrol 93:e58
Hammerman, Marc R (2003) Applications of cell therapy to whole kidney replacement. Curr Opin Nephrol Hypertens 12:1-3
Kikkawa, Yamato; Virtanen, Ismo; Miner, Jeffrey H (2003) Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol 161:187-96

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