Project Start
2001-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2001
Total Cost
$159,355
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chen, Sheldon; Kasama, Yuki; Lee, Joseph S et al. (2004) Podocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes. Diabetes 53:2939-49
Chen, Sheldon; Hoffman, Brenda B; Lee, Joseph S et al. (2004) Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Kidney Int 65:1191-204
Ziyadeh, Fuad N (2004) Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator. J Am Soc Nephrol 15 Suppl 1:S55-7
Chen, Sheldon; Iglesias-de la Cruz, M Carmen; Jim, Belinda et al. (2003) Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun 300:16-22
Rosas, Sylvia E; Joffe, Marshall; Burns, J Eileen et al. (2003) Determinants of successful synthetic hemodialysis vascular access graft placement. J Vasc Surg 37:1036-42
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Iglesias-de la Cruz, M Carmen; Ziyadeh, Fuad N; Isono, Motohide et al. (2002) Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 62:901-13
Bloom, Roy D; O'Connor, Timothy; Cizman, Borut et al. (2002) Intrathymic kidney cells delay the onset of lupus nephritis in MRL-lpr/lpr mice. Int Immunol 14:867-71
Wolf, Gunter; Chen, Sheldon; Han, Dong Cheol et al. (2002) Leptin and renal disease. Am J Kidney Dis 39:1-11
Meyers, Kevin E C; Allen, Juanita; Gehret, Jeffrey et al. (2002) Human antiglomerular basement membrane autoantibody disease in XenoMouse II. Kidney Int 61:1666-73

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