The purpose of the large animal core will be to coordinate and facilitate the in utero gene therapy protocols of all investigators. The personnel supported by this core have extensive experience in general sheep husbandry and in specific aspects of the sheep as an experimental model. This includes extensive experience in survival surgical manipulation of the fetus, with implantation of chronically indwelling fetal catheters and blood flow probes. In the past year we have also developed expertise in surgical approach to 50 day fetuses. The services that the core will provide are: 1. Coordination of all aspects of animal care. 2. Performance of all Surgical Procedures. 3. Post operative Care of transplanted animals. 4. Supervising lambing procedures. The demands on the core as proposed in this grant (12 sheep per year) are well within the capabilities of present personnel and facilities. Therefore, prioritization will involve only the scheduling of surgical time for cell transplantation.

Project Start
1997-09-10
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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