Abstract

Public Health Relevance

This proposal addresses the cellular/molecular mechanisms that cause stress- and obstruction-induced lower urinary tract symptoms (LUTS). LUTS are a major burden for ageing men and women. LUTS cause micturition problems which adversely affect patient quality of life, sleep, increase patient anxiety about the disease, and adversely affect patient mobility, leisure, daily and sexual activities. In many cases, LUTS is a major indication for surgery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
3P50DK052620-12S1
Application #
7940002
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Program Officer
Hoshizaki, Deborah K
Project Start
2009-09-30
Project End
2011-08-31
Budget Start
2009-09-30
Budget End
2011-08-31
Support Year
12
Fiscal Year
2009
Total Cost
$421,456
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Surgery
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Hypolite, Joseph A; Chang, Shaohua; Wein, Alan J et al. (2015) Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. BMC Urol 15:34
Long, C J; Butler, S; Fesi, J et al. (2014) Genetic or pharmacologic disruption of the calcineurin-nuclear factor of activated T-cells axis prevents social stress-induced voiding dysfunction in a murine model. J Pediatr Urol 10:598-604
Marx, James O; Basha, Maureen E; Mohanan, Sunish et al. (2014) Effects of Rho-kinase inhibition on myosin light chain phosphorylation and obstruction-induced detrusor overactivity. Int J Urol 21:319-24
Boopathi, Ettickan; Gomes, Cristiano; Zderic, Stephen A et al. (2014) Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy. Am J Physiol Cell Physiol 307:C542-53
Deng, Maoxian; Boopathi, Ettickan; Hypolite, Joseph A et al. (2013) Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle. Am J Physiol Renal Physiol 305:F1455-65
Eto, Masumi; Kirkbride, Jason A; Chugh, Rishika et al. (2013) Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells. Biochem Biophys Res Commun 434:137-42
Hypolite, Joseph A; Lei, Qi; Chang, Shaohua et al. (2013) Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. Am J Physiol Renal Physiol 304:F451-62
Boopathi, Ettickan; Hypolite, Joseph A; Zderic, Stephen A et al. (2013) GATA-6 and NF-ýýB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction. Mol Cell Biol 33:1085-102
Basha, Maureen E; Chang, Shaohua; Burrows, Lara J et al. (2013) Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis. J Sex Med 10:1219-30
Wei, Wenjie; Howard, Pamela S; Macarak, Edward J (2013) Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter. BMC Urol 13:62

Showing the most recent 10 out of 68 publications