Abstract

The Administrative Core will facilitate interactions among the individual project investigators; coordinate the Center with other scientific programs at KUMC, nationally, and internationally; assist with purchasing of equipment and supplies; help in the preparation of progress reports; assist with the annual PKD symposium to be held in Kansas City; help arrange travel for seminar speakers and External Advisors; and insure the efficient utilization of funds allocated for this Center. The Core will provide staff support for the Center Director, Internal Executive Committee, Biomaterials Core Committee, and Pilot & Feasibility Program Evaluation Committee. Support is requested for Ms. Steffani Webb who will serve in the role of Executive Assistant to the Center Director. She will be located in the Kidney Institute office and thus will be able to interface with other staff in the Kidney Institute as well as in the Division of Nephrology. Funds are also requested for office supplies commensurate with the functions and needs of the multifaceted PKD Center

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK057301-10
Application #
7725504
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
10
Fiscal Year
2008
Total Cost
$9
Indirect Cost

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Parnell, Stephen C; Magenheimer, Brenda S; Maser, Robin L et al. (2018) A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD. Hum Mol Genet 27:3313-3324
Paul, Binu M; Vanden Heuvel, Gregory B (2014) Kidney: polycystic kidney disease. Wiley Interdiscip Rev Dev Biol 3:465-87
Zhou, Xia; Fan, Lucy X; Li, Keguo et al. (2014) SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet 23:1644-55
Swenson-Fields, Katherine I; Vivian, Carolyn J; Salah, Sally M et al. (2013) Macrophages promote polycystic kidney disease progression. Kidney Int 83:855-64
Fan, Lucy X; Li, Xinjian; Magenheimer, Brenda et al. (2012) Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. Kidney Int 81:76-85
Parnell, Stephen C; Puri, Sanjeev; Wallace, Darren P et al. (2012) Protein phosphatase-1ýý interacts with and dephosphorylates polycystin-1. PLoS One 7:e36798
Qiu, Ni; Xiao, Zhousheng; Cao, Li et al. (2012) Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease. PLoS One 7:e46038
Karihaloo, Anil; Koraishy, Farrukh; Huen, Sarah C et al. (2011) Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol 22:1809-14
Nims, Nancy M; Vassmer, Dianne; Maser, Robin L (2011) Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis. Biochemistry 50:349-55
Reif, Gail A; Yamaguchi, Tamio; Nivens, Emily et al. (2011) Tolvaptan inhibits ERK-dependent cell proliferation, Clýýý secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. Am J Physiol Renal Physiol 301:F1005-13

Showing the most recent 10 out of 62 publications