PROVIDED. Scientific: Urinary incontinence (Ul) is a common problem in middle-aged and older women that resultsin tens of billions of dollars in health care expenditures and has been associated with an increased risk of nursing home admissions, falls, and decreased quality of life. The proposed epidemiologic study would follow a well-characterized cohort of 2000 women original enrolled under the Reproductive Risks of Incontinence Study at Kaiser (RRISK). The RRISK cohort is probably unique in being apopulation-based prospective cohort with excellent representation of Black, Asian, Hispanic and non-Hispanic Whitewomen devoted to the study of voiding dysfunction and incontinence. It is also part of the UCSF SpecializedCenter of Research which includes a laboratory-based research group investigating underlying mechanisms for voiding dysfunction and incontinence. The proposed study will continue this highly successful collaboration by investigating questions that have arisen from our clinical and basic science investigations underthe current SCOR. The overall goal of our proposed study is to advance our understanding of the mechanisms of voiding dysfunction and Ul and to facilitate the translational development of novel approaches totreatment and prevention. Specifically, we propose to address the following 6 questions: what is the basis for the two to three fold higher prevalence of stress incontinence in White, comparedto Black or Asian women;what is the longitudinal relationship between pre-diabetes and Ul;do adipocytokines explain the relationship between obesity and incontinence;do phytoestrogens increase the risk of Ul;are estrogen receptor gene polymorphisms risk factors for Ul;and what are risk factors for incident Ul and progression of existingUl. Lay Language: Urinary incontinence is a common problem for which there are limited treatments. Ourstudy will investigate several promising areas to increase our understanding of the mechanisms underlying incontinence and suggest new approaches to treatment and prevention. We will study an ethnicallyand racially diverse group of 2000 women to determine the nature of the recently reported relationship between pre-diabetes and incontinence, and to investigate 3 possible new risk factors for incontinence: adipocytokines (substances secreted by fat cells), phytoestrogens (plant molecules with estrogen-like effects) and genetic variations in estrogen receptors (molecules that allow estrogen to act on cells).

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1)
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University of California San Francisco
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Munaganuru, Nagambika; Van Den Eeden, Stephen K; Creasman, Jennifer et al. (2017) Urine leakage during sexual activity among ethnically diverse, community-dwelling middle-aged and older women. Am J Obstet Gynecol 217:439.e1-439.e8
Duralde, Erin R; Walter, Louise C; Van Den Eeden, Stephen K et al. (2016) Bridging the gap: determinants of undiagnosed or untreated urinary incontinence in women. Am J Obstet Gynecol 214:266.e1-266.e9
Hunter, Mary M; Nakagawa, Sanae; Van Den Eeden, Stephen K et al. (2016) Predictors of impact of vaginal symptoms in postmenopausal women. Menopause 23:40-6
Hsu, Amy; Nakagawa, Sanae; Walter, Louise C et al. (2015) The burden of nocturia among middle-aged and older women. Obstet Gynecol 125:35-43
Huang, Alison J; Gregorich, Steven E; Kuppermann, Miriam et al. (2015) Day-to-Day Impact of Vaginal Aging questionnaire: a multidimensional measure of the impact of vaginal symptoms on functioning and well-being in postmenopausal women. Menopause 22:144-54
Ning, Hongxiu; Lei, Hong-En; Xu, Yong-De et al. (2014) Conversion of adipose-derived stem cells into natural killer-like cells with anti-tumor activities in nude mice. PLoS One 9:e106246
Lin, Ching-Shwun; Lue, Tom F (2013) Defining vascular stem cells. Stem Cells Dev 22:1018-26
Lin, Ching-Shwun; Albersen, Maarten; Xin, Zhongcheng et al. (2013) Phosphodiesterase-5 expression and function in the lower urinary tract: a critical review. Urology 81:480-7
Fehniger, Julia E; Brown, Jeanette S; Creasman, Jennifer M et al. (2013) Childbirth and female sexual function later in life. Obstet Gynecol 122:988-97
Lin, Ching-Shwun; Xin, Zhong-Cheng; Dai, Jican et al. (2013) Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges. Histol Histopathol 28:1109-16

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