The fundamental goal of the Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PCEN) is to support basic, translational, and clinical research, focused on three identified critical pediatric kidney diseases that have major unmet needs. Major components of this goal include to attract outstanding scientific expertise to the study of these focus areas in a multidisciplinary manner, to provide high-resource Cores to support research that utilizes technologies in a timely and efficient manner, and to support novel exploratory pilot projects from promising individuals that represent the future generations of leaders in the focus areas. The primary goal of the Administrative Core is to ensure that the CCHMC PCEN Center functions as a well-coordinated and highly integrated interdisciplinary research platform that synergizes with each Center member's investigation into the three identified critical pediatric kidney disease focus areas. This will be accomplished by organizing interdisciplinary scientific exchanges, providing support in key administrative and secretarial areas, providing web-based communications and information technology, and by administering the Pilot and Feasibility Program and the Enrichment Program. Thus, the Administrative Core will oversee all functions of the CCHMC PCEN Center, including membership, core services, enrichment program, pilot and feasibility program, monitoring scientific output, financial supervision, and budget management The Specific Aims of the Administrative Core are; ? Aim 1. To provide leadership and set the agenda for the research goals of the Center ? Aim 2. To provide administrative, clerical, finance and budget management support to Center members ? Aim 3. To provide biostatistical, bioinformatics, and information technology support to Center members ? Aim 4. To organize an Internal Advisory Board and an External Advisory Board ? Aim 5. To organize and implement the Pilot/Feasibility and Enrichment Programs

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Administrative Core of this Center of Excellence in Nephrology will bring together experts from multiple facets of science to focus their energies on these three disease states to change their dismal outcomes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M3))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cincinnati Children's Hospital Medical Center
United States
Zip Code
Volovelsky, Oded; Gist, Katja M; Terrell, Tara C et al. (2018) Early postoperative measurement of fibroblast growth factor 23 predicts severe acute kidney injury in infants after cardiac surgery?. Clin Nephrol 90:165-171
Gist, Katja M; Cooper, David S; Wrona, Julia et al. (2018) Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit 40:186-194
Bennett, Michael R; Pyles, Olivia; Ma, Qing et al. (2018) Preoperative levels of urinary uromodulin predict acute kidney injury after pediatric cardiopulmonary bypass surgery. Pediatr Nephrol 33:521-526
Albert, Christian; Albert, Annemarie; Bellomo, Rinaldo et al. (2018) Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery. Biomark Med 12:975-985
Basu, Rajit K; Kaddourah, Ahmad; Goldstein, Stuart L et al. (2018) Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study. Lancet Child Adolesc Health 2:112-120
Jotwani, Vasantha; Scherzer, Rebecca; Glidden, David V et al. (2018) Pre-exposure Prophylaxis With Tenofovir Disoproxil Fumarate/Emtricitabine and Kidney Tubular Dysfunction in HIV-Uninfected Individuals. J Acquir Immune Defic Syndr 78:169-174
Valiente-Alandi, IƱigo; Potter, Sarah J; Salvador, Ane M et al. (2018) Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation 138:1236-1252
Jotwani, Vasantha; Katz, Ronit; Ix, Joachim H et al. (2018) Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in Elders. Am J Kidney Dis 72:205-213
Drake, Keri A; Adam, Mike; Mahoney, Robert et al. (2018) Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney. Sci Rep 8:6306
Forster, Catherine S; Jackson, Elizabeth; Ma, Qing et al. (2018) Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders. Pediatr Nephrol 33:1365-1374

Showing the most recent 10 out of 124 publications