The Columbia Center for Children's Environmental Health (CCCEH) proposes an innovative program which builds directly on the investigators' prior research findings in their well characterized cohort of inner city children enrolled prenataly and now being followed into adolescence. Repeated waves of assessment prior to age 11 have shown that high prenatal exposure to polycyclic aromatic hydrocarbons (PAH) is associated with recurrent neurodevelopmental abnormalities, higher rates of obesity, and a failure to increasingly improve the capacity to regulate thought, emotion, and behavior over the course of development. Moreover, the investigators have preliminary evidence from a brain imaging study in our cohort children that early PAH exposure adversely affects the structure of neural systems known to support self-regulatory capacities. Thus the overarching hypothesis of the proposed program of research, around which three research projects are organized, is that prenatal and early childhood exposures to PAH disrupt development of the neural systems that support capacities for self- regulation, and that these PAH-related brain disturbances lead to the emergence or persistence of serious cognitive, emotional, behavioral, and adiposity (hereafter, CEBA) problems during adolescence. The investigators preliminary findings suggest that these PAH-related CEBA problems in adolescence will include increased rates of depression, Attention-Deficit/Hyperactivity Disorder, physical aggression, substance abuse, and risky sexual behaviors. The proposed program will: 1) provide essential evidence of PAH impacts on these significant public health problems; 2) shed light on how PAH affects the development of neural systems in the brain; 3) inform environmental and public health policy; and 4) suggest new avenues for prevention and early intervention. The investigators anticipate that, by providing needed scientific data on a highly prevalent environmental exposure, this research program will have wide-reaching implications for public health and, particularly, for the protection of childrens health. They leverage their strong existing partnership with community groups, especially West Harlem Environmental Action (WE ACT), through their Community Outreach and Translation Core (COTC), to inform the community, policy-makers, and the wider public about scientific findings data on PAH and air and children's health. The investigators' ultimate goal is the prevention of serious adverse PAH-related effects on children's health and development by providing communities, policy-makers, and clinicians with scientific data that will motivate community engagement, strengthen environmental and health policy both locally and nation- wide, and ultimately lead to effective interventions in children affected by air pollution.

Public Health Relevance

Adolescent cognitive, emotional, behavioral, and adiposity (CEBA) problems are highly prevalent and costly, and they represent a major public health problem. Polycyclic aromatic hydrocarbons (PAH) are ubiquitous in the urban environment, generated by combustion of fossil fuel and other organic material; they are not only carcinogenic, but also neurotoxic and obesogenic. Given the ubiquity and known toxicity of PAH, understanding the contribution of PAH to CEBA outcomes from birth through adolescence is necessary to ensure that environmental policies and other interventions adequately protect children during these vulnerable life stages.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
5P50ES009600-19
Application #
9526488
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Gray, Kimberly A
Project Start
1998-11-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
19
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Bansal, Ravi; Peterson, Bradley S (2018) Cluster-level statistical inference in fMRI datasets: The unexpected behavior of random fields in high dimensions. Magn Reson Imaging 49:101-115
Savary, Khalil W; Miller, Rachel L; Arteaga-Solis, Emilio et al. (2018) Infant rhinitis and watery eyes predict school-age exercise-induced wheeze, emergency department visits and respiratory-related hospitalizations. Ann Allergy Asthma Immunol 120:278-284.e2
Perera, Frederica P; Wheelock, Kylie; Wang, Ya et al. (2018) Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems. Environ Res 160:506-513
Morgenstern, Rachelle; Whyatt, Robin M; Insel, Beverly J et al. (2017) Phthalates and thyroid function in preschool age children: Sex specific associations. Environ Int 106:11-18
Buckley, Jessie P; Engel, Stephanie M; Braun, Joseph M et al. (2016) Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology 27:449-58
Whyatt, Robin M; Liu, Xinhua; Rauh, Virginia A et al. (2012) Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age. Environ Health Perspect 120:290-5
Tang, Wan-yee; Levin, Linda; Talaska, Glenn et al. (2012) Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-? in cord white blood cells. Environ Health Perspect 120:1195-200
Wallace, Deborah (2011) Discriminatory mass de-housing and low-weight births: scales of geography, time, and level. J Urban Health 88:454-68
Horton, Megan K; Jacobson, J Bryan; McKelvey, Wendy et al. (2011) Characterization of residential pest control products used in inner city communities in New York City. J Expo Sci Environ Epidemiol 21:291-301
Jung, Kyung Hwa; Bernabé, Kerlly; Moors, Kathleen et al. (2011) Effects of Floor Level and Building Type on Residential Levels of Outdoor and Indoor Polycyclic Aromatic Hydrocarbons, Black Carbon, and Particulate Matter in New York City. Atmosphere (Basel) 2:96-109

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