The long-term goal of the Center for Childhood Asthma in the Urban Environment (CCAUE) is to understand how exposures to indoor and outdoor airborne particulate matter and allergens may result in airway inflammation and respiratory morbidity in children with asthma living in the inner city of Baltimore and to identify novel opportunities and strategies to reduce morbidity associated with these exposures. The overarching hypothesis guiding the Center's proposed research is that indoor air pollution (particulate matter and allergens) produces increased oxidative stress which leads to increased airway inflammation and asthma morbidity in children. The investigators have assembled a multidisciplinary and integrated team of researchers to investigate the role oxidative stress, and airway inflammation in asthma morbidity in order to develop new biomarkers of effect, provide insight into susceptible genotypes, offer better clinical management, and to identify opportunities for intervention (environmental and pharmacologic). This program outlines a multidisciplinary program directed to address this hypothesis and long-term goal. This Center application includes the following two clinically-oriented and mechanistically-oriented research projects: Clinically-Oriented Research Projects: Project 1 - Domestic Indoor PM and Childhood Asthma Morbidity;Project 2 - Oxidative Stress/Inflammation during PM Nasal Challenge and Mechanistically-Oriented Research Projects: Project 3 - Nrf2 Dependent Regulation of Oxidative Stress in Asthma;Project 4 - Mechanisms of PM-Induced Dendritic Cell Activation. INTEGRATED (clinical and basic) and INTERDISCIPLINARY NATURE OF PROGRAM

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Specialized Center (P50)
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Study Section
Special Emphasis Panel (ZES1-JAB-C (DI))
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Gray, Kimberly A
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Johns Hopkins University
Schools of Medicine
United States
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Wu, Tianshi David; Eakin, Michelle N; Rand, Cynthia S et al. (2018) In-Home Secondhand Smoke Exposure Among Urban Children With Asthma: Contrasting Households With and Without Residential Smokers. J Public Health Manag Pract :
Wu, Tianshi David; Brigham, Emily P; Peng, Roger et al. (2018) Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. J Allergy Clin Immunol Pract 6:2157-2159.e5
Grant, Torie; Aloe, Charles; Perzanowski, Matthew et al. (2017) Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children. J Allergy Clin Immunol Pract 5:1008-1014.e1
McCormack, Meredith C; Paulin, Laura M; Gummerson, Christine E et al. (2017) Colder temperature is associated with increased COPD morbidity. Eur Respir J 49:
Peters, Kamau O; Williams, D' Ann L; Abubaker, Salahadin et al. (2017) Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. J Expo Sci Environ Epidemiol 27:290-298
Nnodum, Benedicta Nneoma; McCormack, Meredith C; Putcha, Nirupama et al. (2017) Impact of Physical Activity on Reporting of Childhood Asthma Symptoms. Lung 195:693-698
Paulin, Laura M; Williams, D 'Ann L; Peng, Roger et al. (2017) 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma. Environ Res 159:118-123
Miele, Catherine H; Jaganath, Devan; Miranda, J Jaime et al. (2016) Urbanization and Daily Exposure to Biomass Fuel Smoke Both Contribute to Chronic Bronchitis Risk in a Population with Low Prevalence of Daily Tobacco Smoking. COPD 13:186-95
Kolahdooz, Fariba; Butler, Jennie L; Christiansen, Karina et al. (2016) Food and Nutrient Intake in African American Children and Adolescents Aged 5 to 16 Years in Baltimore City. J Am Coll Nutr 35:205-16
McCormack, Meredith C; Belli, Andrew J; Waugh, Darryn et al. (2016) Respiratory Effects of Indoor Heat and the Interaction with Air Pollution in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 13:2125-2131

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