While ambient air pollution has been implicated as a risk factor for asthma exacerbations, interpretation of findings from epidemiologic studies has been hampered by uncertainties in exposures and in the precise nature of the airway responses. The overall goal of the proposed study is to advance our understanding of the influence of diesel exhaust exposures in acute asthma exacerbations by linking innovative exposure and outcome measures. We propose to optimize and test a new miniature """"""""smart"""""""" personal sampling system for size- and composition-classified particulate matter, and to implement the system in a study of personal xposures and acute airway responses among children enrolled in CCCEH. The smart sampler will monitor personal exposures for 30 asthmatic and 30 non-asthmatic children ages 9/10 to DEP/BC (Diesel Exhaust Particulates-Black Carbon), multiple elements, and PM2.5 and will distinguish exposures occurring in three key environments (at home, at school and other/in-transit). For each child, we will collect a sequence of six 48-hour personal samples, timed to coincide with 2-week average home indoor and outdoor measurements proposed in project 1. We will quantify and compare personal exposures to DEP/BC at home, school, and other/transit, and will analyze the relationship between personal DEP/BC exposures and concurrently- measured home indoor/outdoor DEP/BC concentrations. Based on particle elemental composition, we also will analyze the extent to which personal PM2.5 exposures are driven by traffic-related particle emissions. At the completion of each 48-hour monitoring period, we will measure exhaled-breath biomarkers (cys- leukotrienes, NO, 8-isoprostane) and adenosine, lung function by spirometry, and respiratory symptoms (i.e., wheeze) for each of the 60 children. Statistical analyses and hypothesis testing will 1) determine the relative importance of home, school, and other/in-transit exposure environments for personal exposures, 2) test for acute effects of personal DEP/BC exposures on exhaled-breath 8-isoprostane, NO, pH, cys-leukotrienes and adenosine, and 3) determine whether average levels of these biomarkers vary across children as a function of asthma status and/or average DEP/BC exposure.
The aims and methods proposed here will both advance our understanding of acute airway effects of DEP/BC and complement the aims of the other projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
5P50ES015905-05
Application #
8279274
Study Section
Special Emphasis Panel (ZES1)
Project Start
2011-06-01
Project End
2013-05-31
Budget Start
2011-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2011
Total Cost
$321,556
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Bansal, Ravi; Peterson, Bradley S (2018) Cluster-level statistical inference in fMRI datasets: The unexpected behavior of random fields in high dimensions. Magn Reson Imaging 49:101-115
Savary, Khalil W; Miller, Rachel L; Arteaga-Solis, Emilio et al. (2018) Infant rhinitis and watery eyes predict school-age exercise-induced wheeze, emergency department visits and respiratory-related hospitalizations. Ann Allergy Asthma Immunol 120:278-284.e2
Lovinsky-Desir, Stephanie; Lawrence, Jennifer; Jung, Kyung Hwa et al. (2018) Assessment of exposure to air pollution in children: Determining whether wearing a personal monitor affects physical activity. Environ Res 166:340-343
Jung, Kyung Hwa; Lovinsky-Desir, Stephanie; Yan, Beizhan et al. (2017) Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization. Clin Epigenetics 9:61
Jung, Kyung Hwa; Torrone, David; Lovinsky-Desir, Stephanie et al. (2017) Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children. Respir Res 18:63
Lovinsky-Desir, Stephanie; Miller, Rachel L; Bautista, Joshua et al. (2016) Differences in Ambient Polycyclic Aromatic Hydrocarbon Concentrations between Streets and Alleys in New York City: Open Space vs. Semi-Closed Space. Int J Environ Res Public Health 13:
Miller, Rachel L; Yan, Zhonghai; Maher, Christina et al. (2016) Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression and DNA methylation of the Bdnf gene. Neuroepigenetics 5:11-18
Jung, Kyung Hwa; Lovinsky-Desir, Stephanie; Perzanowski, Matthew et al. (2015) Repeatedly high polycyclic aromatic hydrocarbon exposure and cockroach sensitization among inner-city children. Environ Res 140:649-56
Peterson, Bradley S; Rauh, Virginia A; Bansal, Ravi et al. (2015) Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 72:531-40
Jung, Kyung Hwa; Perzanowski, Matthew; Rundle, Andrew et al. (2014) Polycyclic aromatic hydrocarbon exposure, obesity and childhood asthma in an urban cohort. Environ Res 128:35-41

Showing the most recent 10 out of 64 publications