Abstract

The Center brings together a number of investigators with specialties in pharmacokinetics, clinical pharmacology, analytical methodology, drug metabolism, immunopharmacology, drug delivery, molecular biology, cardiology, transplant surgery, laboratory medicine, pediatrics, anesthesiology and biostatistics. The overall area of concern of the group is to investigate and model the relationship between drug kinetics and dynamics and to discover, understand and quantify modifications of drug kinetics and/or dynamics caused by altered physiology or pathology (disease state), as well as to investigate new methodologies to be utilized in drug delivery. Six scientific units (and a core) examine and attempt to correlate input processes of drug into the body, distribution of drug into the general circulation and to sites of action, and drug loss processes with pharmacodynamic measures of pharmacologic effect, clinical effect and toxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM026691-17
Application #
2174762
Study Section
Special Emphasis Panel (SRC (05))
Project Start
1979-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1996-07-31
Support Year
17
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Chen, Zhe; Brown, Emery N; Barbieri, Riccardo (2010) Characterizing nonlinear heartbeat dynamics within a point process framework. IEEE Trans Biomed Eng 57:1335-47
Chen, Zhe; Brown, Emery N; Barbieri, Riccardo (2009) Assessment of autonomic control and respiratory sinus arrhythmia using point process models of human heart beat dynamics. IEEE Trans Biomed Eng 56:1791-802
Egge-Jacobsen, Wolfgang; Unger, Matthias; Niemann, Claus U et al. (2004) Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit 26:546-62
Hebert, Mary F; Wacher, Vincent J; Roberts, John P et al. (2003) Pharmacokinetics of cyclosporine pre- and post-liver transplantation. J Clin Pharmacol 43:38-42
Benet, L Z; Cummins, C L (2001) The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev 50 Suppl 1:S3-11
Wacher, V J; Salphati, L; Benet, L Z (2001) Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 46:89-102
Stanley, G B; Poolla, K; Siegel, R A (2000) Threshold modeling of autonomic control of heart rate variability. IEEE Trans Biomed Eng 47:1147-53
Christians, U; Jacobsen, W; Serkova, N et al. (2000) Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl 748:41-53
Serkova, N; Litt, L; Leibfritz, D et al. (2000) The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol 129:485-92
Jager, W; Correia, M A; Bornheim, L M et al. (1999) Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos 27:1505-11

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