This is a multi-disciplinary, trauma center application for Study of Wound Healing and Wound Infection. It consists of a core section and five parts: 1. Studies on oxygenation, perfusion, and healing in humans. 2. Tissue flaps and a study of the physiologic dimension of wound infection. 3. The growth environment and diabetes. 4. Wound healing angiogenesis 5. Control of collagen synthesis in wounds The central theme is the coordinated dissection of wound extracellular environment and the effects of its components on infection, collagen synthesis, angiogenesis, and fibroplasia. The goal is to understand why and how injuries heal; what stops them from healing and disposes toward infection; and what can be done to assure useful repair free of infection.
| Gimbel, Michael L; Rollins, Mark D; Fukaya, Eri et al. (2009) Monitoring partial and full venous outflow compromise in a rabbit skin flap model. Plast Reconstr Surg 124:796-803 |
| Ogino, Tetsuya; Than, Tin Aung; Hosako, Mutsumi et al. (2009) Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol 643:451-61 |
| Hunt, Thomas K; Aslam, Rummana S; Beckert, Stefan et al. (2007) Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal 9:1115-24 |
| Hansen, Scott L; Dosanjh, Amarjit; Young, David M et al. (2006) Hemangiomas and homeobox gene expression. J Craniofac Surg 17:767-71 |
| Rosen, Noah A; Hopf, Harriet W; Hunt, Thomas K (2006) Perflubron emulsion increases subcutaneous tissue oxygen tension in rats. Wound Repair Regen 14:55-60 |
| Hopf, Harriet W; Gibson, Jeffrey J; Angeles, Adam P et al. (2005) Hyperoxia and angiogenesis. Wound Repair Regen 13:558-64 |
| Fries, Richard B; Wallace, William A; Roy, Sashwati et al. (2005) Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res 579:172-81 |
| Hansen, Scott L; Young, David M; Boudreau, Nancy J (2003) HoxD3 expression and collagen synthesis in diabetic fibroblasts. Wound Repair Regen 11:474-80 |
| Trabold, Odilo; Wagner, Silvia; Wicke, Corinna et al. (2003) Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen 11:504-9 |
| Boudreau, Nancy; Myers, Connie (2003) Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 5:140-6 |
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