This section deals with approaches to delineate mechanisms that control collagen synthesis/deposition with angiogenic activities in wounds.
Our aim i s to explore how metabolic conditions in wounds activate collagen gene transcription and collagen synthesis presumably via ADPRibosylation. Oxidant insults and heat shock injury also involve ADPRibosylation. As an alternative means to implicate ADPR mechanisms, as well as a means to open an area of investigation of wound pathology, we propose to determine whether oxygen radicals, DNA damage/repair, and heat shock proteins modulate collagen synthesis. These studies will be conducted in early passage culture of human skin fibroblasts. These studies are expected to provide a firm basis of understanding the how and why collagen synthesis and angiogenesis start, slow down, and stop in healing tissue.
| Gimbel, Michael L; Rollins, Mark D; Fukaya, Eri et al. (2009) Monitoring partial and full venous outflow compromise in a rabbit skin flap model. Plast Reconstr Surg 124:796-803 |
| Ogino, Tetsuya; Than, Tin Aung; Hosako, Mutsumi et al. (2009) Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol 643:451-61 |
| Hunt, Thomas K; Aslam, Rummana S; Beckert, Stefan et al. (2007) Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal 9:1115-24 |
| Hansen, Scott L; Dosanjh, Amarjit; Young, David M et al. (2006) Hemangiomas and homeobox gene expression. J Craniofac Surg 17:767-71 |
| Rosen, Noah A; Hopf, Harriet W; Hunt, Thomas K (2006) Perflubron emulsion increases subcutaneous tissue oxygen tension in rats. Wound Repair Regen 14:55-60 |
| Hopf, Harriet W; Gibson, Jeffrey J; Angeles, Adam P et al. (2005) Hyperoxia and angiogenesis. Wound Repair Regen 13:558-64 |
| Fries, Richard B; Wallace, William A; Roy, Sashwati et al. (2005) Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res 579:172-81 |
| Hansen, Scott L; Young, David M; Boudreau, Nancy J (2003) HoxD3 expression and collagen synthesis in diabetic fibroblasts. Wound Repair Regen 11:474-80 |
| Trabold, Odilo; Wagner, Silvia; Wicke, Corinna et al. (2003) Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen 11:504-9 |
| Boudreau, Nancy; Myers, Connie (2003) Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 5:140-6 |
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