Abstract

We propose to study the effect of the administration to human volunteers of cortisol or endotoxin or both on cytokine secretion by circulating mononuclear cells and neutrophils on expression of cytokine messenger RNAs in these cells, on the percentage of circulating T lymphocytes and T cell subsets and on the proliferative response of circulating lymphocytes to T cell mitogens. These investigations are designed to determine whether the administration of endotoxin or cortisol or both mimic the abnormalities of the immune response noted in seriously injured patients. We will also study the effect of the administration of growth hormone to patients with serious injury on the immunologic abnormalities customarily found in these individuals including altered cytokine production, decreased T cell activation and immunosuppressive serum. Finally, we will study the affect of the administration of low dose interleukin-2 and ibuprofen to seriously injured patients on resistance to infection, mortality and cytokine production, T cell activation and on the appearance of immunosuppressive serum.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM036428-09
Application #
3778302
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Jacobs, D O; Wong, M (2000) Metabolic assessment. World J Surg 24:1460-7
Ziegler, T R; Bye, R L; Persinger, R L et al. (1998) Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. Am J Med Sci 315:4-10
Hill, A G; Siegel, J; Rounds, J et al. (1997) Metabolic responses to interleukin-1: centrally and peripherally mediated. Ann Surg 225:246-51
Mann, D V; Robinson, M K; Rounds, J D et al. (1997) Superiority of blood over saline resuscitation from hemorrhagic shock: a 31P magnetic resonance spectroscopy study. Ann Surg 226:653-61
Suzuki, H; Rounds, J D; Wilmore, D W (1996) Does multifrequency bioelectrical impedance relate to body composition? J Surg Res 65:63-9
Denno, R; Rounds, J D; Faris, R et al. (1996) Glutamine-enriched total parenteral nutrition enhances plasma glutathione in the resting state. J Surg Res 61:35-8
Ziegler, T R; Mantell, M P; Chow, J C et al. (1996) Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration. Am J Physiol 271:G866-75
Denno, R; Rounds, J D; Faris, R et al. (1996) The enhanced effect of parenteral nutrition on hepatotoxicity. Nutrition 12:30-5
Santos, A A; Wilmore, D W (1996) The systemic inflammatory response: perspective of human endotoxemia. Shock 6 Suppl 1:S50-6
Byrne, T A; Nompleggi, D J; Wilmore, D W (1996) Advances in the management of patients with intestinal failure. Transplant Proc 28:2683-90

Showing the most recent 10 out of 93 publications