Abstract

This proposal will test the hypothesis that an exercise program and the daily administration of recombinant human growth hormone will promote recovery to full physiological function in children after severe burn injury. An intervention study will be performed in which clinically relevant outcome parameters will be quantified at 3-month intervals up to one year post-burn. Half of the patients will be randomized to receive 0.05 mg/kg/d of recombinant human growth hormone or placebo injection throughout the year. Each group will be further randomized to participate in a 3-month exercise-conditioning program offered at the Shriners Burns Hospital, or receive standard home rehabilitation. Thus, 4 groups of patients will be studied up to one year post-burn. Endpoints of this study will be knee heights and standing height, body weight, lean body mass determined by 40K-counter and dual energy x-ray absorptiometry (DEXA), muscle strength, bone density, bone histomorphometry, and scar formation by the Vancouver Scar Scale. Identification and quantitation of types III, IV, and VII collagen will also be made from skin biopsies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM060338-03
Application #
6607077
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$166,566
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Murton, Andrew; Bohanon, Fredrick J; Ogunbileje, John O et al. (2018) Sepsis Increases Muscle Proteolysis in Severely Burned Adults, But Does Not Impact Whole-Body Lipid or Carbohydrate Kinetics. Shock :
Malagaris, Ioannis; Herndon, David N; Polychronopoulou, Efstathia et al. (2018) Determinants of skeletal muscle protein turnover following severe burn trauma in children. Clin Nutr :
El Ayadi, Amina; Prasai, Anesh; Wang, Ye et al. (2018) ?-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. J Invest Dermatol 138:1645-1655
Hundeshagen, Gabriel; Collins, Vanessa N; Wurzer, Paul et al. (2018) A Prospective, Randomized, Controlled Trial Comparing the Outpatient Treatment of Pediatric and Adult Partial-Thickness Burns with Suprathel or Mepilex Ag. J Burn Care Res 39:261-267
Patel, Dipen D; Rosenberg, Marta; Rosenberg, Laura et al. (2018) Poverty, population density, and the epidemiology of burns in young children from Mexico treated at a U.S. pediatric burn facility. Burns 44:1269-1278
Berger, Nathan A; Besson, Valerie C; Boulares, A Hamid et al. (2018) Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 175:192-222
Ogunbileje, John O; Herndon, David N; Murton, Andrew J et al. (2018) The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma. J Burn Care Res 39:100-108
Rivas, Eric; Herndon, David N; Cambiaso-Daniel, Janos et al. (2018) Quantification of an Exercise Rehabilitation Program for Severely Burned Children: The Standard of Care at Shriners Hospitals for Children®-Galveston. J Burn Care Res 39:889-896
Guillory, Ashley N; Clayton, Robert P; Prasai, Anesh et al. (2018) Buprenorphine-Sustained Release Alters Hemodynamic Parameters in a Rat Burn Model. J Surg Res 232:154-159
?apek, Karel D; Culnan, Derek M; Desai, Manubhai H et al. (2018) Fifty Years of Burn Care at Shriners Hospitals for Children, Galveston. Ann Plast Surg 80:S90-S94

Showing the most recent 10 out of 253 publications