Abstract

Project 1 presents a comprehensive study for the development of novel chemistry for the synthesis of alkene peptide isoteres and vinylogous amino acids, including their cyclopropyl analogs, the investigation of the uses of these peptide mimetics in chiral separation and catalysis , and biological evaluation of their potential as anti-estrogens and protein phosphatase inhibitors. This project is highly translational not only in the interaction with Projects 2 and 3 and the DOS Core facility in this cooperative grant application, but also in the collaboration of synthetic with analytical chemists, biologists, and pharmacologists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
1P50GM067082-01
Application #
6684800
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2002-09-30
Project End
2007-09-29
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Saydmohammed, Manush; Vollmer, Laura L; Onuoha, Ezenwa O et al. (2018) A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules 23:
Wissel, Gloria; Deng, Feng; Kudryavtsev, Pavel et al. (2017) A structure-activity relationship study of ABCC2 inhibitors. Eur J Pharm Sci 103:60-69
Gleixner, Amanda M; Hutchison, Daniel F; Sannino, Sara et al. (2017) N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione. Mol Pharmacol 92:564-575
Brand, Rhonda M; Epperly, Michael W; Stottlemyer, J Mark et al. (2017) A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. J Invest Dermatol 137:576-586
McCabe, Stephanie R; Wipf, Peter (2017) Eight-Step Enantioselective Total Synthesis of (-)-Cycloclavine. Angew Chem Int Ed Engl 56:324-327
Manos-Turvey, Alexandra; Al-Ashtal, Hiba A; Needham, Patrick G et al. (2016) Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorg Med Chem Lett 26:5087-5091
Brummond, Kay M; Kocsis, Laura S (2015) Intramolecular didehydro-Diels-Alder reaction and its impact on the structure-function properties of environmentally sensitive fluorophores. Acc Chem Res 48:2320-9
Rupakheti, Chetan; Virshup, Aaron; Yang, Weitao et al. (2015) Strategy to discover diverse optimal molecules in the small molecule universe. J Chem Inf Model 55:529-37
Ma, Jing; Lim, Chaemin; Sacher, Joshua R et al. (2015) Mitochondrial targeted ?-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett 25:4828-33
Wissel, Gloria; Kudryavtsev, Pavel; Ghemtio, Leo et al. (2015) Exploring the structure-activity relationships of ABCC2 modulators using a screening approach. Bioorg Med Chem 23:3513-25

Showing the most recent 10 out of 166 publications