New project 6: The costs and benefits of environmental sensing in budding yeast (Ramanathan) (#33)We have used single-cell experiments, modeling and theory to investigate the costs and benefits of astarvation response (sporulation) in budding yeast. We investigated the variability between individuals in thekinetics of decision-making using sporulation as a model. We found 2.5 fold variability in the timing ofsporulation after a population of cells is transferred from rich to starvation medium. By following fluorescentproteins, we divided the period before the second meiotic division into three periods: the time from the start ofstarvation to induction of the first wave of targets of Ime1, the time from the onset of the first wave to Ml andthe time from Ml to Mil. The duration of the three phases is independent of each other demonstrating that theyare each subject to intrinsic variability that is the result of differences in the levels of different molecules. Thiswork38 will form the basis for our future experiments, which are designed to investigate the costs and benefitsof different strategies for sensing and responding to environmental variables. Sharad Ramanathan became aBauer Fellow in 2004 and joined CMB in 2006.
| Westerman, Erica L; VanKuren, Nicholas W; Massardo, Darli et al. (2018) Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice. Curr Biol 28:3469-3474.e4 |
| Bonham, Kevin S; Wolfe, Benjamin E; Dutton, Rachel J (2017) Extensive horizontal gene transfer in cheese-associated bacteria. Elife 6: |
| Tamari, Zvi; Yona, Avihu H; Pilpel, Yitzhak et al. (2016) Rapid evolutionary adaptation to growth on an 'unfamiliar' carbon source. BMC Genomics 17:674 |
| Kim, Wook; Levy, Stuart B; Foster, Kevin R (2016) Rapid radiation in bacteria leads to a division of labour. Nat Commun 7:10508 |
| Muller, Nicolas; Piel, Matthieu; Calvez, Vincent et al. (2016) A Predictive Model for Yeast Cell Polarization in Pheromone Gradients. PLoS Comput Biol 12:e1004795 |
| Wahl, Mary E; Murray, Andrew W (2016) Multicellularity makes somatic differentiation evolutionarily stable. Proc Natl Acad Sci U S A 113:8362-7 |
| Hormoz, Sahand; Singer, Zakary S; Linton, James M et al. (2016) Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements. Cell Syst 3:419-433.e8 |
| Renn, Suzy C P; O'Rourke, Cynthia F; Aubin-Horth, Nadia et al. (2016) Dissecting the Transcriptional Patterns of Social Dominance across Teleosts. Integr Comp Biol 56:1250-1265 |
| Kastman, Erik K; Kamelamela, Noelani; Norville, Josh W et al. (2016) Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species. MBio 7: |
| Lavrentovich, Maxim O; Wahl, Mary E; Nelson, David R et al. (2016) Spatially Constrained Growth Enhances Conversional Meltdown. Biophys J 110:2800-2808 |
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