New project 6: The costs and benefits of environmental sensing in budding yeast (Ramanathan) (#33)We have used single-cell experiments, modeling and theory to investigate the costs and benefits of astarvation response (sporulation) in budding yeast. We investigated the variability between individuals in thekinetics of decision-making using sporulation as a model. We found 2.5 fold variability in the timing ofsporulation after a population of cells is transferred from rich to starvation medium. By following fluorescentproteins, we divided the period before the second meiotic division into three periods: the time from the start ofstarvation to induction of the first wave of targets of Ime1, the time from the onset of the first wave to Ml andthe time from Ml to Mil. The duration of the three phases is independent of each other demonstrating that theyare each subject to intrinsic variability that is the result of differences in the levels of different molecules. Thiswork38 will form the basis for our future experiments, which are designed to investigate the costs and benefitsof different strategies for sensing and responding to environmental variables. Sharad Ramanathan became aBauer Fellow in 2004 and joined CMB in 2006.
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